Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp

Stephen T Deyrup; James B Gloer; Kerry O'Donnell; Donald T Wicklow

doi:10.1021/np060546k

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Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp

Journal article

Peer reviewed

Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp

Stephen T Deyrup, James B Gloer, Kerry O'Donnell and Donald T Wicklow

Journal of natural products (Washington, D.C.), Vol.70(3), pp.378-382

03/2007

DOI: 10.1021/np060546k

PMID: 17284074

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Abstract

Four new triterpenoid glycosides, kolokosides A-D (1-4), along with the known compound 19,20-epoxycytochalasin N, were isolated from cultures of a Hawaiian wood-decay fungus (Xylaria sp.). The structures and relative configurations of 1-4 were determined primarily by analysis of NMR data, and the absolute configuration of 1 was assigned by application of the exciton chirality method. Compound 1 exhibited activity against Gram-positive bacteria.

Anti-Bacterial Agents - chemistry

Anti-Bacterial Agents - isolation & purification

Anti-Bacterial Agents - pharmacology

Bacillus subtilis - drug effects

Candida albicans - drug effects

Escherichia coli - drug effects

Glucose - analysis

Glycosides - chemistry

Glycosides - isolation & purification

Glycosides - pharmacology

Gram-Positive Bacteria - drug effects

Hawaii

Molecular Structure

Nuclear Magnetic Resonance, Biomolecular

Staphylococcus aureus - drug effects

Triterpenes - chemistry

Triterpenes - isolation & purification

Triterpenes - pharmacology

Xylariales - chemistry

Details

Title: Subtitle: Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp
Creators: Stephen T Deyrup - Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
James B Gloer
Kerry O'Donnell
Donald T Wicklow
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.70(3), pp.378-382
DOI: 10.1021/np060546k
PMID: 17284074
ISSN: 0163-3864
eISSN: 1520-6025
Language: English
Date published: 03/2007
Academic Unit: Chemistry
Record Identifier: 9984216575102771

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