Journal article
L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity
ACG case reports journal, Vol.6(8), p.e00194
2019
DOI: 10.14309/crj.0000000000000194
PMCID: PMC6791645
PMID: 31737724
Abstract
Asparaginase is a part of combination chemotherapy for acute lymphoblastic leukemia. We present a 58-year-old woman with refractory acute lymphoblastic leukemia who developed asparaginase-induced hepatotoxicity after receiving intravenous PEG-L-asparaginase-based chemotherapy. The patient presented with hyperbilirubinemia and transaminitis. The patient was diagnosed with drug-induced liver injury due to PEG-L-asparaginase after a thorough evaluation for all other causes and received treatment with L-carnitine and vitamin B complex with normalization of liver numbers. Hepatic dysfunction was attributed to depletion of L-asparagine and glutamine, which impairs mitochondrial β-oxidation and induces steatosis. We reiterate the role of L-carnitine and vitamin B complex for the treatment of asparaginase-induced hepatotoxicity.
© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
Details
- Title: Subtitle
- L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity
- Creators
- Sumant Arora - University of IowaJagpal Klair - Virginia Mason Medical CenterAndrew M Bellizzi - University of IowaTomohiro Tanaka - University of Iowa
- Resource Type
- Journal article
- Publication Details
- ACG case reports journal, Vol.6(8), p.e00194
- DOI
- 10.14309/crj.0000000000000194
- PMID
- 31737724
- PMCID
- PMC6791645
- NLM abbreviation
- ACG Case Rep J
- ISSN
- 2326-3253
- eISSN
- 2326-3253
- Language
- English
- Date published
- 2019
- Academic Unit
- Gastroenterology and Hepatology; Pathology; Internal Medicine
- Record Identifier
- 9984199921002771
Metrics
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