L-triiodothyronine at a slightly over physiologic dose increases leucine flux, which suggests an increase in protein degradation in normal subjects

E Tsalikian; V S Lim

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L-triiodothyronine at a slightly over physiologic dose increases leucine flux, which suggests an increase in protein degradation in normal subjects

Journal article

Peer reviewed

L-triiodothyronine at a slightly over physiologic dose increases leucine flux, which suggests an increase in protein degradation in normal subjects

E Tsalikian and V S Lim

The Journal of laboratory and clinical medicine, Vol.114(2), pp.171-175

08/1989

PMID: 2754304

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Abstract

The present study was undertaken to determine whether minor alterations of serum thyroid hormone concentration have an effect on plasma amino acid kinetics. Flux rates of 2H3-labeled leucine, 15N-labeled leucine, and 2H3-labeled alanine were determined in the basal state and after a 7-day course of L-triiodothyronine (T3) supplementation in seven normal adult subjects. A small dose of T3 was given (0.8 microgram/kg/day) that resulted in only slightly higher than physiologic serum T3 concentration. After T3 treatment, leucine carbon flux increased from 1.22 +/- 0.05 to 1.40 +/- 0.05 mumol/kg/minute (p less than 0.001) and leucine nitrogen flux increased from 2.10 +/- 0.15 to 2.48 +/- 0.14 mumol/kg/minute (p less than 0.005), but alanine carbon flux did not change significantly, going from 6.26 +/- 0.67 to 6.58 +/- 0.58 (p = not significant). Because the experiment was performed in the postabsorptive state, increased leucine flux after T3 treatment suggests accelerated protein degradation.

Deuterium

Alanine - blood

Nitrogen - metabolism

Leucine - blood

Humans

Middle Aged

Thyroxine - blood

Male

Nitrogen Isotopes

Triiodothyronine - blood

Adult

Female

Kinetics

Thyrotropin - blood

Triiodothyronine - pharmacology

Details

Title: Subtitle: L-triiodothyronine at a slightly over physiologic dose increases leucine flux, which suggests an increase in protein degradation in normal subjects
Creators: E Tsalikian - Veterans Administration Medical Center, Iowa City, Iowa
V S Lim
Resource Type: Journal article
Publication Details: The Journal of laboratory and clinical medicine, Vol.114(2), pp.171-175
PMID: 2754304
NLM abbreviation: J Lab Clin Med
ISSN: 0022-2143
eISSN: 1532-6543
Publisher: Elsevier
Grant note: RR 59 / NCRR NIH HHS
Language: English
Date published: 08/1989
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Nephrology; Internal Medicine
Record Identifier: 9984093319502771

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