LDL reduction: how low should we go and is it safe?

Jennifer G Robinson

doi:10.1007/s11886-008-0076-3

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Journal article

LDL reduction: how low should we go and is it safe?

Jennifer G Robinson

Current cardiology reports, Vol.10(6), pp.481-487

11/2008

DOI: 10.1007/s11886-008-0076-3

PMID: 18950559

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Abstract

High-dose statin therapy or combination statin treatment is necessary for most patients to achieve aggressive low-density lipoprotein cholesterol goals. Adding ezetimibe or bile acid sequestrants appears unlikely to increase the risk of myopathy. Although the combination of niacin or fenofibrate with moderate-dose statins appears to be reasonably safe, the safety of combination with high-dose statins has yet to be determined. To enhance patient outcomes, attention must be paid to characteristics that predict muscle and hepatic statin toxicity when considering using high-dose statin or combination statin therapy.

Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage

Humans

Ezetimibe

Allylamine - therapeutic use

Allylamine - adverse effects

Fenofibrate - therapeutic use

Niacin - therapeutic use

Cholesterol, LDL - blood

Muscular Diseases - chemically induced

Drug Therapy, Combination

Colesevelam Hydrochloride

Stroke - prevention & control

Hyperlipidemias - drug therapy

Risk Factors

Allylamine - analogs & derivatives

Azetidines - adverse effects

Coronary Artery Disease - prevention & control

Cholesterol, LDL - drug effects

Coronary Artery Disease - drug therapy

Hyperlipidemias - prevention & control

Anticholesteremic Agents - adverse effects

Disease Progression

Anticholesteremic Agents - therapeutic use

Azetidines - therapeutic use

Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use

Hypolipidemic Agents - therapeutic use

Details

Title: Subtitle: LDL reduction: how low should we go and is it safe?
Creators: Jennifer G Robinson - Lipid Research Clinic, 200 Hawkins Drive SE 226 GH, Iowa City, IA 52242, USA. jennifer-g-robinson@uiowa.edu
Resource Type: Journal article
Publication Details: Current cardiology reports, Vol.10(6), pp.481-487
Publisher: United States
DOI: 10.1007/s11886-008-0076-3
PMID: 18950559
ISSN: 1523-3782
eISSN: 1534-3170
Language: English
Date published: 11/2008
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983996094502771

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