Journal article
LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era
Leukemia & Lymphoma, Vol.53(6), pp.1105-1112
06/01/2012
DOI: 10.3109/10428194.2011.638717
PMID: 22066713
Abstract
Both LMO2 (LIM domain only 2) mRNA and protein expression in diffuse large B-cell lymphoma (DLBCL) have been associated with superior survival. However, a role for germline genetic variation in LMO2 has not been previously reported. Immunohistochemistry (IHC) for LMO2 was conducted on tumor tissue from diagnostic biopsies, and 20 tag single nucleotide polymorphisms (SNPs) from LMO2 were genotyped from germline DNA. LMO2 IHC positivity was associated with superior survival (hazard ratio [HR] = 0.55; 95% confidence interval [CI] 0.31-0.97). Four LMO2 SNPs (rs10836127, rs941940, rs750781, rs1885524) were associated with survival after adjusting for LMO2 IHC and clinical factors (p < 0.05), and one of these SNPs (rs941940) was also associated with IHC positivity (p = 0.02). Compared to a model with clinical factors only (c-statistic = 0.676), adding the four SNPs (c-statistic = 0.751) or LMO2 IHC (c-statistic = 0.691) increased the predictive ability of the model, while inclusion of all three factors (c-statistic = 0.754) did not meaningfully add predictive ability above a model with clinical factors and the four SNPs. In conclusion, germline genetic variation in LMO2 was associated with DLBCL prognosis and provided slightly stronger predictive ability relative to LMO2 IHC status.
Details
- Title: Subtitle
- LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era
- Creators
- James R Cerhan - Division of EpidemiologyYasodha Natkunam - Department of Pathology, Stanford University School of MedicineLindsay M Morton - Division of Cancer Epidemiology and Genetics, National Cancer InstituteMatthew J Maurer - Division of Biomedical Statistics and InformaticsYan Asmann - Division of Biomedical Statistics and InformaticsThomas M Habermann - Division of HematologyMohammad A Vasef - Department of Pathology, University of New MexicoWendy Cozen - Department of Preventive Medicine, University of Southern CaliforniaCharles F Lynch - Department of Epidemiology, University of IowaCristine Allmer - Division of Biomedical Statistics and InformaticsSusan L Slager - Division of Biomedical Statistics and InformaticsIzidore S Lossos - Division of Oncology-Hematology, Department of Medicine, University of MiamiStephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer InstituteNathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer InstitutePatricia Hartge - Division of Cancer Epidemiology and Genetics, National Cancer InstituteAhmet Dogan - Department of Laboratory Medicine and Pathology, College of Medicine, Mayo ClinicSophia S Wang - Department of Population Sciences
- Resource Type
- Journal article
- Publication Details
- Leukemia & Lymphoma, Vol.53(6), pp.1105-1112
- DOI
- 10.3109/10428194.2011.638717
- PMID
- 22066713
- NLM abbreviation
- Leuk Lymphoma
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 06/01/2012
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996082302771
Metrics
62 Record Views