Journal article
LIPOPROTEINS AS MEDIATORS FOR THE EFFECTS OF ALCOHOL CONSUMPTION AND CIGARETTE SMOKING ON CARDIOVASCULAR MORTALITY: RESULTS FROM THE LIPID RESEARCH CLINICS FOLLOW-UP STUDY
American journal of epidemiology, Vol.126(4), pp.629-637
10/1987
DOI: 10.1093/oxfordjournals.aje.a114702
PMID: 3631053
Abstract
Criqui, M. H. (Dept of Community and Family Medicine, U. of California, San Diego, La Jolla, CA 92093), L. D. Cowan, H. A. Tyroler, S. Bangdiwala, Q. Heiss, R. B. Wallace, and R. Conn. Upoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Upid Research Clinics Follow-up Study. Am J Epidemiol 1987; 126:629–37. Because alcohol consumption is associated with increased high density lipoprotein (HDL) cholesterol and decreased low density lipoprotein (LDL) cholesterol, and cigarette smoking is associated with lower HDL cholesterol and higher LDL cholesterol, there has been speculation that the protective effect of moderate alcohol consumption and/or the noxious effect of cigarette smoking for cardiovascular disease might be mediated in large part by a lipoprotein mechanism. The authors examined this question in a prospective study of 7,481 men and women in 10 North American populations initially seen in 1972–1976 and followed for an average of 8.5 years. Moderate alcohol consumption was weakly protective for cardiovascular disease, while cigarette smoking was strongly and significantly associated with cardiovascular disease mortality. As expected, LDL cholesterol was positively related and HDL cholesterol was inversely related to cardiovascular disease mortalIty. However, multivarlable analysis of cardiovascular disease mortality alternately excluding and including HDL cholesterol and LDL cholesterol as covariates indicated that the effect of alcohol consumption on cardiovascular disease mortality was independent of an LDL cholesterol pathway and only partially mediated by an HDL cholesterol pathway, while the effect of cigarette smoking was independent of both the HDL cholesterol and LDL cholesterol pathways, suggesting alternative biologic mechanisms of action for both alcohol consumption and cigarette smoking on cardiovascular disease.
Details
- Title: Subtitle
- LIPOPROTEINS AS MEDIATORS FOR THE EFFECTS OF ALCOHOL CONSUMPTION AND CIGARETTE SMOKING ON CARDIOVASCULAR MORTALITY: RESULTS FROM THE LIPID RESEARCH CLINICS FOLLOW-UP STUDY
- Creators
- MICHAEL H. Criqui - University of California San DiegoLINDA D. Cowan - University of OklahomaH. A. Tyroler - University of North Carolina at Chapel HillSHRIKANT Bangdiwala - University of North Carolina at Chapel HillGERARDO Heiss - University of North Carolina at Chapel HillROBERT B. Wallace - University of IowaRICHARD Cohn - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.126(4), pp.629-637
- DOI
- 10.1093/oxfordjournals.aje.a114702
- PMID
- 3631053
- NLM abbreviation
- Am J Epidemiol
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 10/1987
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363603002771
Metrics
18 Record Views