LRP8 is a receptor for tick-borne encephalitis virus
Abstract
Details
- Title: Subtitle
- LRP8 is a receptor for tick-borne encephalitis virus
- Creators
- Eva Mittler - Albert Einstein College of MedicineAlexandra L Tse - Albert Einstein College of MedicinePham-Tue-Hung Tran - Karolinska InstitutetCatalina Florez - United States Army Medical Research Institute of Infectious DiseasesJavier Janer - Albert Einstein College of MedicineRenata Varnaite - Karolinska InstitutetEzgi Kasikci - Albert Einstein College of MedicineVasantha Kumar Mv - Albert Einstein College of MedicineMichaela Loomis - United States Army Medical Research Institute of Infectious DiseasesWanda Christ - Karolinska InstitutetErik Cazares - United States Army Medical Research Institute of Infectious DiseasesRussell R Bakken - United States Army Medical Research Institute of Infectious DiseasesCaroline K Martin - Albert Einstein College of MedicineXiankun Zeng - United States Army Medical Research Institute of Infectious DiseasesJo Lynne Raymond - United States Army Medical Research Institute of Infectious DiseasesMansoureh Shahsavani - Karolinska InstitutetSara Khanal - United States Army Medical Research Institute of Infectious DiseasesEric R Wilkinson - United States Army Medical Research Institute of Infectious DiseasesRischa Maya Oktavia - Institut PasteurMegan M Slough - Albert Einstein College of MedicineDenise Haslwanter - Albert Einstein College of MedicineJulianna Han - University of ChicagoJacob Berrigan - Albert Einstein College of MedicineEbba Rosendal - Umeå UniversityMargaret Kielian - Albert Einstein College of MedicineBalaji Manicassamy - University of IowaAnna K Överby - Umeå UniversityAnna Falk - Karolinska InstitutetGiovanna Barba-Spaeth - Institut PasteurFelix A Rey - Institut PasteurJonas Klingström - Linköping UniversityEvripidis Gavathiotis - Albert Einstein College of MedicineAndrew S Herbert - United States Army Medical Research Institute of Infectious DiseasesKartik Chandran - Albert Einstein College of MedicineSara Gredmark-Russ - Karolinska University Hospital
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.646(8086), pp.945-952
- DOI
- 10.1038/s41586-025-09500-2
- PMID
- 40993380
- NLM abbreviation
- Nature
- ISSN
- 1476-4687
- eISSN
- 1476-4687
- Publisher
- NATURE PORTFOLIO
- Grant note
- Einstein National Cancer Institute's cancer center: P30CA013330 US National Institutes of Health: R01AI132633 Marianne and Marcus Wallenberg FoundationRegion Stockholm (Clinical Research Appointment)Swedish Research Council: 2020-06224 US National Institute of Allergy and Infectious Diseases: R21AI182834 Congressionally Directed Medical Research Programs: HT9425-24-1-0873 French National Research Agency: ANR-18-CE92-0006, ANR-22-CE35-0004, ANR-10-LABX-62-10 IBEID
We thank K. Paez, E. Valencia and M. Ramirez, K. Dempsey, C. O'Brien, A. I. Kuehne and N. M. Josleyn for laboratory management and technical assistance; K. Cogliano for programmatic and administrative support; K. Stiasny for providing TBEV monoclonal antibodies B2 and B4; the members of the Einstein Epigenomics Core and Computational Genomics Core for NGS analysis and data analysis support; the staff at the Einstein Flow Cytometry Core Facility (supported by the Einstein National Cancer Institute's cancer center support grant P30CA013330) for surface flow cytometry sorting of cell lines; the members of the Einstein Macromolecular Therapeutics Development Facility for protein characterization by size-exclusion chromatography; and the staff at the Karolinska Institutet ANA Futura BSL3 Core Facility (supported by the Infrastructure Board at Karolinska Institutet) for enabling virus studies under high-containment. US National Institutes of Health grant R01AI132633 (K.C.); Marianne and Marcus Wallenberg Foundation (S.G.-R.); Region Stockholm (Clinical Research Appointment) (S.G.-R.); Swedish Research Council (Dnr 2020-06249 and 2021-06602) (S.G.-R.); Swedish Research Council (Dnr 2020-06224) (A.K.O.); US National Institute of Allergy and Infectious Diseases grants R01AI165932 and R01AI174584 (B.M.); Congressionally Directed Medical Research Programs grant HT9425-24-1-0873 (C.F.); US National Institute of Allergy and Infectious Diseases grant R21AI182834 (C.K.M.); and French National Research Agency grants ANR-18-CE92-0006, ANR-22-CE35-0004 and ANR-10-LABX-62-10 IBEID (F.A.R.). Opinions, conclusions, interpretations and recommendations are those of the authors and are not necessarily endorsed by the US Department of the Army, the US Department of Defense or the US Department of Health and Human Services.
- Language
- English
- Electronic publication date
- 09/24/2025
- Date published
- 10/23/2025
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984966335502771