Journal article
Laboratory findings in CD4(+) large granular lymphocytoses
International journal of laboratory hematology, Vol.32(1 Pt 1), pp.e9-e16
02/2010
DOI: 10.1111/j.1751-553X.2008.01109.x
PMID: 20089001
Abstract
Large granular lymphocytic (LGL) leukemia is an uncommon disorder of mature T or natural killer (NK) cells. Most T-LGL proliferations are CD3(+)/CD8(+), although rare CD4(+) clonal T-LGL expansions have been reported. We report the clinicopathologic features of eight patients with aberrant CD4(+), cytotoxic T-cell lymphocytoses. Median follow-up was 29 months (range 8-100), during which all were alive without requirement for therapy. Four of eight patients had an additional malignancy; none had a history of rheumatoid arthritis, lymphadenopathy or hepatosplenomegaly. Morphologic expansions of granulated lymphocytes were evident in 6/8. All had immunophenotypically aberrant populations of CD4(+) T cells with uniform, moderate or bright CD56. Seven of eight expressed CD57, and four were CD8(partial dim +). Abnormal levels of expression of two or more T-cell antigens were seen in all cases. All tested cases were Tgamma PCR positive. Our results support that CD4(+) T-LGL lymphocytosis is a clonal disorder with clinicopathologic characteristics distinct from the more common CD8(+) variant.
Details
- Title: Subtitle
- Laboratory findings in CD4(+) large granular lymphocytoses
- Creators
- H Olteanu - Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. holteanu@mcw.eduN J KarandikarC EshoaS H Kroft
- Resource Type
- Journal article
- Publication Details
- International journal of laboratory hematology, Vol.32(1 Pt 1), pp.e9-e16
- Publisher
- England
- DOI
- 10.1111/j.1751-553X.2008.01109.x
- PMID
- 20089001
- ISSN
- 1751-5521
- eISSN
- 1751-553X
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984047892902771
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