Journal article
Lack of Association of Herpes Simplex Virus Type 2 Seropositivity With the Progression of HIV Infection in the HERS Cohort
American journal of epidemiology, Vol.173(7), pp.837-844
04/01/2011
DOI: 10.1093/aje/kwq432
PMCID: PMC3105280
PMID: 21372062
Abstract
Many studies have chronicled the "epidemiologic synergy" between human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2). HIV adversely affects the natural history of HSV-2 and results in more frequent and severe HSV-2 reactivation. Few longitudinal studies, however, have examined whether HSV-2 is associated with increased HIV plasma viral loads or decreased CD4 counts. The authors estimated the effect of HSV-2 seropositivity on HIV RNA viral load and on CD4 count over time among 777 HIV-seropositive US women not receiving suppressive HSV-2 therapy in the HIV Epidemiology Research Study (1993-2000). Linear mixed models were used to assess the effect of HSV-2 on log HIV viral load and CD4 count/mm(3) prior to widespread initiation of highly active antiretroviral therapy. Coinfection with HSV-2 was not associated with HIV RNA plasma viral loads during study follow-up. There was a statistically significant association between HSV-2 seropositivity and CD4 count over time, but this difference was small and counterintuitive at an increase of 8 cells/mm(3) (95% confidence interval: 2, 14) per year among HSV-2-seropositive women compared with HSV-2-seronegative women. These data do not support a clinically meaningful effect of baseline HSV-2 seropositivity on the trajectories of HIV plasma viral loads or CD4 counts.
Details
- Title: Subtitle
- Lack of Association of Herpes Simplex Virus Type 2 Seropositivity With the Progression of HIV Infection in the HERS Cohort
- Creators
- Brooke E. Hoots - Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USAMichael G. Hudgens - University of North Carolina at Chapel HillStephen R. Cole - University of North Carolina at Chapel HillCaroline C. KingRobert S. Klein - Icahn School of Medicine at Mount SinaiKenneth H. Mayer - Brown UniversityAnne M. Rompalo - Johns Hopkins UniversityJack D. Sobel - Wayne State UniversityDenise J. Jamieson - Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USAJennifer S. Smith - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.173(7), pp.837-844
- DOI
- 10.1093/aje/kwq432
- PMID
- 21372062
- PMCID
- PMC3105280
- NLM abbreviation
- Am J Epidemiol
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Grant note
- T32AI070114-01 / National Institute of Allergy and Infectious Diseases (NIAID); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 04/01/2011
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446420302771
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