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Lack of Effectiveness of Tissue Plasminogen Activator 20 or More Days After Vitrectomy
Journal article   Peer reviewed

Lack of Effectiveness of Tissue Plasminogen Activator 20 or More Days After Vitrectomy

James C Folk, Jonathan M Hershey and Michael B Rivers
Archives of ophthalmology (1960), Vol.109(5), pp.614-614
05/01/1991
DOI: 10.1001/archopht.1991.01080050020010
PMID: 1902660

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Abstract

Tissue plasminogen activator (TPA) causes the resolution of intraocular fibrin after vitrectomy, even at the low dose of 6 μg.1 Experiments show, however, that it can increase the risk of intraocular bleeding, especially if used soon after surgery.2 It may be better to wait as long as possible after surgery before using TPA. We report two cases in which TPA was ineffective in resolving intraocular fibrin when administered 20 days or more after a vitrectomy.

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