Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study

Nelly Mauras; Roy W Beck; Katrina J Ruedy; Craig Kollman; William V Tamborlane; H Peter Chase; Bruce A Buckingham; Eva Tsalikian; Stuart Weinzimer; Andrea D Booth; Dongyuan Xing; Diabetes Research in Children Network (DirecNet) Accuracy Study

doi:10.1016/j.jpeds.2004.03.042

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Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study

Journal article

Peer reviewed

Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study

Nelly Mauras, Roy W Beck, Katrina J Ruedy, Craig Kollman, William V Tamborlane, H Peter Chase, Bruce A Buckingham, Eva Tsalikian, Stuart Weinzimer, Andrea D Booth, …

The Journal of pediatrics, Vol.144(6), pp.770-775

06/2004

DOI: 10.1016/j.jpeds.2004.03.042

PMCID: PMC2248702

PMID: 15192625

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https://www.ncbi.nlm.nih.gov/pmc/articles/2248702View

Open Access

Abstract

The workup of hypoglycemia requires frequent glucose sampling. We designed these studies to determine if the Continuous Glucose Monitoring System (CGMS) and the GlucoWatch G2 Biographer (GW2B) are sufficiently accurate to use in nondiabetic children. Study design Fifteen healthy children (aged 9-17 years, 11 boys) wore a GW2B and a CGMS during a 24-hour period, and reference serum glucose was measured hourly during the day and half-hourly overnight. Compared with the reference glucose, the median absolute difference in concentrations measured by the GW2B (487 pairs) was 13 mg/dL, and the difference measured by the CGMS was 17 mg/dL (668 pairs), with 30% and 42% of values using the GW2B and CGMS, respectively, deviating >20 mg/dL from the reference value. The GW2B reported values <60 mg/dL in 73% of subjects, the CGMS in 60% of subjects. In none of these episodes was serum glucose truly low. Spurious high glucose concentrations also were observed with the sensors. The mean reference glucose was lowest at 5 am (89 mg/dL) and highest at 11:30 pm (106 mg/dL) during the 24-hour period. Neither the CGMS nor the GW2B is accurate enough to establish population standards of the glycemic profile of healthy children and cannot be recommended in the workup of hypoglycemia in nondiabetic youth.

Hypoglycemia - diagnosis

Reproducibility of Results

Blood Glucose - analysis

Diagnostic Techniques, Endocrine

Humans

Adolescent

Female

Male

Child

Details

Title: Subtitle: Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study
Creators: Nelly Mauras - DirecNet Coordinating Center, Tampa, Florida, USA
Roy W Beck
Katrina J Ruedy
Craig Kollman
William V Tamborlane
H Peter Chase
Bruce A Buckingham
Eva Tsalikian
Stuart Weinzimer
Andrea D Booth
Dongyuan Xing
Diabetes Research in Children Network (DirecNet) Accuracy Study
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.144(6), pp.770-775
DOI: 10.1016/j.jpeds.2004.03.042
PMID: 15192625
PMCID: PMC2248702
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: U10 HD041890 / NICHD NIH HHS RR00059 / NCRR NIH HHS U10 HD041915-01 / NICHD NIH HHS RR00070-41 / NCRR NIH HHS U10 HD041906 / NICHD NIH HHS U10 HD041919-01 / NICHD NIH HHS M01 RR000069 / NCRR NIH HHS U10 HD041918-01 / NICHD NIH HHS M01 RR000070 / NCRR NIH HHS RR06022 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS U10 HD041906-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041908-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD041919-0 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS U01 HD041890-01 / NICHD NIH HHS M01 RR000059 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS HD041915 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
Language: English
Date published: 06/2004
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093351402771

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