Lack of association between 25(OH)D levels and incident type 2 diabetes in older women

Jennifer G Robinson; Joann E Manson; Joseph Larson; Simin Liu; Yiqing Song; Barbara V Howard; Lawrence Phillips; James M Shikany; Matthew Allison; J David Curb; Karen C Johnson; Nelson Watts

doi:10.2337/dc10-1632

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Lack of association between 25(OH)D levels and incident type 2 diabetes in older women

Journal article

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Peer reviewed

Lack of association between 25(OH)D levels and incident type 2 diabetes in older women

Jennifer G Robinson, Joann E Manson, Joseph Larson, Simin Liu, Yiqing Song, Barbara V Howard, Lawrence Phillips, James M Shikany, Matthew Allison, J David Curb, …

Diabetes care, Vol.34(3), pp.628-634

03/2011

DOI: 10.2337/dc10-1632

PMCID: PMC3041195

PMID: 21289227

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Abstract

To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. A post hoc analysis of three nested case-control studies of fractures, colon cancer, and breast cancer that measured serum 25(OH)D levels in women participating in the Women's Health Initiative (WHI) Clinical Trials and Observational Study who were free of prevalent diabetes at baseline. Diabetes was defined as self-report of physician diagnosis or receiving insulin or oral hypoglycemic medication. We used inverse probability weighting to make the study population representative of the WHI population as a whole. Weighted logistic regression models compared 25(OH)D levels (divided into quartiles, clinical cut points [<50, 50-<75, ≥ 75 nmol/L], or as a continuous variable) using the distribution of control subjects and adjusted for multiple confounding factors. Of 5,140 women (mean age 66 years) followed for an average of 7.3 years, 317 (6.2%) developed diabetes. Regardless of the cut points used or as a continuous variable, 25(OH)D levels were not associated with diabetes incidence in either age or fully adjusted models. Nor was any relationship found between 25(OH)D and incident diabetes when evaluated by strata of BMI, race/ethnicity, or randomization status in the Calcium Vitamin D trial. Lower serum 25(OH)D levels were not associated with increased risk of developing type 2 diabetes in this racially and ethnically diverse population of postmenopausal women.

Humans

Middle Aged

Colonic Neoplasms - epidemiology

Fractures, Bone - epidemiology

Case-Control Studies

Diabetes Mellitus, Type 2 - epidemiology

Fractures, Bone - blood

Vitamin D - blood

Diabetes Mellitus, Type 2 - blood

Breast Neoplasms - blood

Colonic Neoplasms - blood

Female

Aged

Breast Neoplasms - epidemiology

Details

Title: Subtitle: Lack of association between 25(OH)D levels and incident type 2 diabetes in older women
Creators: Jennifer G Robinson - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA. jennifer-g-robinson@uiowa.edu
Joann E Manson
Joseph Larson
Simin Liu
Yiqing Song
Barbara V Howard
Lawrence Phillips
James M Shikany
Matthew Allison
J David Curb
Karen C Johnson
Nelson Watts
Resource Type: Journal article
Publication Details: Diabetes care, Vol.34(3), pp.628-634
Publisher: United States
DOI: 10.2337/dc10-1632
PMID: 21289227
PMCID: PMC3041195
ISSN: 0149-5992
eISSN: 1935-5548
Grant note: N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH32100-2 / WHI NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32118-32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS N01WH32105-6 / WHI NIH HHS N01WH24152 / WHI NIH HHS
Language: English
Date published: 03/2011
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995104602771

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