Journal article
Lack of association of trinucleotide repeat polymorphisms in the very-low-density lipoprotein receptor gene with Alzhelner's disease
Annals of neurology, Vol.39(6), pp.800-803
06/1996
DOI: 10.1002/ana.410390617
Abstract
Inheritance of the apolipoprotein E ε 4 allele is a risk factor for Alzheimer's disease (AD). A recent report studying Japanese patients suggested that a polymorphism of a trinucleotide repeat in the 5′ untranslated region of an apolipoprotein E receptor, the very-low-density lipoprotein receptor, is genetically associated with AD, with overrepresentation of the allele containing five copies of the repeat. We determined the allele frequencies of the very-low-density lipoprotein receptor in 3 white populations totaling 469 individuals. In contrast to the previous report, we found no differences in allele frequencies between case patients and control subjects. The discrepancy could be due to differences in Japanese and white populations. Nonetheless, these data weaken the likelihood that this polymorphism in the very-low-density lipoprotein receptor gene is strongly associated with AD.
Details
- Title: Subtitle
- Lack of association of trinucleotide repeat polymorphisms in the very-low-density lipoprotein receptor gene with Alzhelner's disease
- Creators
- Haeyong Chung - Neurology Service, Massachusetts General Hopspital, BostonCarol T. Roberts - Cardiovascular Research Center, Massachusetts General Hopspital, BostonSteven Greenberg - Neurology Service, Massachusetts General Hopspital, BostonG. William Rebeck - Harvard UniversityRichard Christie - Neurology Service, Massachusetts General Hopspital, BostonRobert Wallace - University of IowaHoward J. Jacob - Cardiovascular Research Center, Massachusetts General Hopspital, BostonBradley T. Hyman - Harvard University
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.39(6), pp.800-803
- DOI
- 10.1002/ana.410390617
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 4
- Language
- English
- Date published
- 06/1996
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364451402771
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