Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects

Adolfo Correa; Suzanne M Gilboa; Lorenzo D Botto; Cynthia A Moore; Charlotte A Hobbs; Mario A Cleves; Tiffany J RIEHLE-COLARUSSO; D Kim Waller; E. Albert Reece; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2011.12.018

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Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects

Journal article

Open access

Peer reviewed

Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects

Adolfo Correa, Suzanne M Gilboa, Lorenzo D Botto, Cynthia A Moore, Charlotte A Hobbs, Mario A Cleves, Tiffany J RIEHLE-COLARUSSO, D Kim Waller, E. Albert Reece and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.206(3), pp.218-221

2012

DOI: 10.1016/j.ajog.2011.12.018

PMCID: PMC4915337

PMID: 22284962

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Abstract

Objective The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid. Study Design The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid. Results The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid. Conclusion The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus.

Biological and medical sciences

Diabetes. Impaired glucose tolerance

Endocrine pancreas. Apud cells (diseases)

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Gynecology. Andrology. Obstetrics

Medical sciences

Details

Title: Subtitle: Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects
Creators: Adolfo Correa - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States
Suzanne M Gilboa - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States
Lorenzo D Botto - Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, United States
Cynthia A Moore - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States
Charlotte A Hobbs - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR, United States
Mario A Cleves - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR, United States
Tiffany J RIEHLE-COLARUSSO - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States
D Kim Waller - Houston Health Science Center, University of Texas School of Public Health, Houston, TX, United States
E. Albert Reece - Departments of Obstetrics and Gynecology, Medicine, and Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.206(3), pp.218-221
DOI: 10.1016/j.ajog.2011.12.018
PMID: 22284962
PMCID: PMC4915337
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Elsevier
Language: English
Date published: 2012
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214717002771

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