Lamina cribrosa thickness correlated with posterior scleral thickness and axial length in monkeys

Jost B Jonas; Jan N Kutscher; Songhomitra Panda-Jonas; Sohan S Hayreh

doi:10.1111/aos.13070

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Lamina cribrosa thickness correlated with posterior scleral thickness and axial length in monkeys

Journal article

Open access

Peer reviewed

Lamina cribrosa thickness correlated with posterior scleral thickness and axial length in monkeys

Jost B Jonas, Jan N Kutscher, Songhomitra Panda-Jonas and Sohan S Hayreh

Acta ophthalmologica (Oxford, England), Vol.94(8), pp.e693-e696

12/2016

DOI: 10.1111/aos.13070

PMID: 27156570

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Abstract

To explore associations of lamina cribrosa thickness with axial length and thickness of the posterior sclera in monkeys. Examining histological sections by light microscopy, we measured the thickness of the lamina cribrosa and posterior sclera and axial length. The study included 28 animals (28 eyes) with a mean age of 13.3 ± 4.9 years (range: 3-24 years) and mean axial length of 18.9 ± 1.4 mm (range: 17-21 mm) (22 eyes after experimental temporary central retinal artery occlusion; four eyes after a permanent occlusion of the posterior ciliary artery; and two eyes without any intervention). Mean thickness of the lamina cribrosa was 167 ± 30 μm (range: 115-273 μm). Thinner lamina cribrosa thickness was significantly associated with longer axial length (standardized correlation coefficient beta: -0.42; p = 0.026), with thinner sclera at the posterior pole (beta: 0.56; p = 0.002) and with thinner sclera at the disc border (beta: 0.55; p = 0.002). Lamina cribrosa thickness was not significantly related to temporary central retinal artery occlusion (p = 0.14) or to permanent posterior ciliary artery occlusion (p = 0.49) or age (p = 0.46). As in humans, lamina cribrosa thickness in non-glaucomatous monkeys got thinner with longer axial length and with thinner posterior sclera. These data may be of interest for studies on the process of emmetropization/myopization in monkeys, and they may be of interest for the studies on the biomechanics of the optic nerve head.

Ciliary Arteries - pathology

Axial Length, Eye - pathology

Humans

Intraocular Pressure - physiology

Organ Size

Male

Posterior Eye Segment

Macaca mulatta

Animals

Retinal Artery Occlusion - pathology

Arterial Occlusive Diseases - pathology

Sclera - pathology

Tonometry, Ocular

Female

Optic Disk - pathology

Details

Title: Subtitle: Lamina cribrosa thickness correlated with posterior scleral thickness and axial length in monkeys
Creators: Jost B Jonas - Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
Jan N Kutscher - Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
Songhomitra Panda-Jonas - Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
Sohan S Hayreh - Departments of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Acta ophthalmologica (Oxford, England), Vol.94(8), pp.e693-e696
Publisher: England
DOI: 10.1111/aos.13070
PMID: 27156570
ISSN: 1755-375X
eISSN: 1755-3768
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: EY‐1576
Language: English
Date published: 12/2016
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979977302771

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