Journal article
Laminar profiles of functional activity in the human brain
NeuroImage (Orlando, Fla.), Vol.34(1), pp.74-84
01/01/2007
DOI: 10.1016/j.neuroimage.2006.08.020
PMID: 17011213
Abstract
Functional magnetic resonance imaging (fMRI) data were obtained in human visual cortex using sub-millimeter voxels at a field strength of 3 T. Reliable functional signals were largely confined to the gray matter and these responses measure the retinotopic organization of visual cortex. Functional signals were further characterized with respect to their laminar position within the cortical gray matter. The laminar response profiles during our visuospatial attention task, normalized for cortical thickness, had a stereotypical shape, with a peak in the superficial gray matter and declining in the deeper layers. The thickness of the sheet producing functional signals was in excellent agreement with the estimated structural thickness of the gray matter throughout early visual cortex (error < 0.5 mm). Thickness measurements were highly repeatable from session-to-session (error < 0.4 mm). Hence, it is feasible and useful to use high-resolution fMRI to measure laminar activity profiles. The ability to distinguish signals arising in different lamina has significant potential scientific and clinical applications.
Details
- Title: Subtitle
- Laminar profiles of functional activity in the human brain
- Creators
- David Ress - Brown UniversityGary H Glover - Stanford UniversityJunjie Liu - Stanford UniversityBrian Wandell - Stanford University
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.34(1), pp.74-84
- DOI
- 10.1016/j.neuroimage.2006.08.020
- PMID
- 17011213
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Grant note
- NEI03164 / PHS HHS RR09784 / NCRR NIH HHS
- Language
- English
- Date published
- 01/01/2007
- Academic Unit
- Neurology
- Record Identifier
- 9984303020202771
Metrics
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