Journal article
Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection
Journal of cutaneous pathology, Vol.34(7), pp.565-570
2007
DOI: 10.1111/j.1600-0560.2006.00663.x
PMID: 17576336
Abstract
Background: Decreased numbers of Langerhans cells (LCs) in the cervix of human immunodeficiency virus (HIV)-infected women are believed to contribute to the progression of human papilloma virus (HPV)-related squamous intraepithelial lesions. However, this impairment of local immunity has not been well studied in the vulva. The objective of this study was to compare the S100+ LC density in high-grade vulvar intraepithelial neoplasia (VIN) in HIV-positive and HIV-negative women.
Methods: HIV-positive and HIV-negative patients with high-grade VIN, 48 (55%) and 40 (45%), respectively, were identified by retrospective chart review. Smoking status of patients was noted. The mean LC count per high-power field (HPF) was determined using S100 immunohistochemical staining. In situ hybridization was performed to detect HPV DNA types 16 and 18.
Results: Mean S100+ LC counts for HIV-positive and HIV-negative patients were 5.82 and 9.86 per HPF, respectively (p = 0.0026). LC counts in HIV-positive and HIV-negative patients were compared between smoking and nonsmoking groups (HIV-positive p = 0.4812, HIV-negative p = 0.2821).
Conclusions: HIV-positive patients with high-grade VIN had significantly lower LC counts compared with HIV-negative patients. This suggests that local vulvar immunity as evaluated by S100+ LCs is impaired in HIV-positive women, possibly contributing to the progression of HPV-related vulvar lesions.
Details
- Title: Subtitle
- Langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection
- Creators
- Janis M TAUBE - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United StatesAndrew D NICHOLS - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United StatesLynette S BORNMAN - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United StatesDaniel M BORNMAN - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United StatesJay Brooks JACKSON - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Journal of cutaneous pathology, Vol.34(7), pp.565-570
- Publisher
- Blackwell; Oxford
- DOI
- 10.1111/j.1600-0560.2006.00663.x
- PMID
- 17576336
- ISSN
- 0303-6987
- eISSN
- 1600-0560
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047785302771
Metrics
16 Record Views