Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Talha S Siddiqui; Ashish Jani; Florence Williams; Robert N Muller; Luce Vander Elst; Sophie Laurent; Fang Yao; Youssef Zaim Wadghiri; Marc A Walters

doi:10.1016/j.jcis.2009.04.096

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Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Journal article

Peer reviewed

Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Talha S Siddiqui, Ashish Jani, Florence Williams, Robert N Muller, Luce Vander Elst, Sophie Laurent, Fang Yao, Youssef Zaim Wadghiri and Marc A Walters

Journal of colloid and interface science, Vol.337(1), pp.88-96

2009

DOI: 10.1016/j.jcis.2009.04.096

PMID: 19527906

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https://orbi.umons.ac.be/bitstream/20.500.12907/22999/1/MULLER-2009-12-journal.pdfView

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Abstract

Uptake of gadolinium by nitrilotriacetate tethered to the surface of a silver nanoparticle. The gadolinium containing colloid induces the relaxation of proton spins in aqueous solution. This paper describes colloidal particles that are designed to induce hyper-intensity contrast ( T 1 relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)] 2− and (2) [Gd(cystine–NTA) 2] 3−, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r 1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s −1 mM −1, respectively, as compared to 4.7 s −1 mM −1 for the clinical agent Magnevist TM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s −1 mM −1.

Nanoparticles

Silver

Relaxivity

MRI

Monolayer protected

Contrast

Longitudinal relaxation

Details

Title: Subtitle: Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging
Creators: Talha S Siddiqui - Department of Chemistry, New York University, New York, NY 10003, USA
Ashish Jani - Department of Chemistry, New York University, New York, NY 10003, USA
Florence Williams - Department of Chemistry, New York University, New York, NY 10003, USA
Robert N Muller - Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Université de Mons-Hainaut, Mons, Belgium
Luce Vander Elst - Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Université de Mons-Hainaut, Mons, Belgium
Sophie Laurent - Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Université de Mons-Hainaut, Mons, Belgium
Fang Yao - School of Dentistry, New York University, New York, NY 10016, USA
Youssef Zaim Wadghiri - School of Medicine, Department of Radiology, New York University, New York, NY 10016, USA
Marc A Walters - Department of Chemistry, New York University, New York, NY 10003, USA
Resource Type: Journal article
Publication Details: Journal of colloid and interface science, Vol.337(1), pp.88-96
DOI: 10.1016/j.jcis.2009.04.096
PMID: 19527906
NLM abbreviation: J Colloid Interface Sci
ISSN: 0021-9797
eISSN: 1095-7103
Publisher: Elsevier Inc
Language: English
Date published: 2009
Academic Unit: Iowa Neuroscience Institute; Chemistry
Record Identifier: 9984065469402771

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