Journal article
Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats
Circulation journal : official journal of the Japanese Circulation Society, Vol.78(9), pp.2284-U394
2014
DOI: 10.1253/circj.CJ-14-0027
PMID: 24976508
Abstract
Background: It has been shown that increased short-term blood pressure (BP) variability (BPV) aggravates hypertensive cardiac remodeling in spontaneously hypertensive rats (SHRs) through a cardiac angiotensin II (angII) system. However, little was known about the renal damage induced by large BPV. Thus, histological changes in the kidney were investigated and candesartan, an angII type 1 receptor blocker (ARB), was also examined to see whether it would prevent renal damage in SHRs with large BPV.
Methods and Results: Bilateral sinoaortic denervation (SAD) was performed in SHRs to create a model of a combination of hypertension and large BPV. SAD increased BPV without changing mean BP. Seven weeks later, SAD induced patchy, wedge-shaped, focal sclerotic lesions accompanied by interstitial fibrosis and ischemic changes of glomeruli and tubules in the cortex. The pre-glomerular arterioles adjacent to the sclerotic lesions showed arteriolosclerotic changes associated with vascular smooth muscle cell proliferation and extracellular matrix deposition, leading to the luminal narrowing and occlusion. Chronic treatment with a subdepressor dose of candesartan prevented not only arteriolosclerotic changes but also cortical sclerotic lesions in SHRs with SAD without changing BPV.
Conclusions: Large BPV aggravates pre-glomerular arteriolosclerosis, which results in the cortical sclerotic changes in SHRs through a local angII-mediated mechanism. This study raised the possibility that ARB is useful for renal protection in patients who have a combination of hypertension and increased BPV.
Details
- Title: Subtitle
- Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats
- Creators
- Yuji Aoki - Kurume UniversityHisashi Kai - Kurume UniversityHidemi Kajimoto - Kurume UniversityHiroshi Kudo - Kurume UniversityNarimasa Takayama - Kurume UniversitySuguru Yasuoka - Kurume UniversityTakahiro Anegawa - Kurume UniversityYoshiko Iwamoto - Kurume UniversityHiroki Uchiwa - Kurume UniversityKenji Fukuda - Kurume UniversityMasayoshi Kage - Kurume University HospitalSeiya Kato - Saiseikai Fukuoka General HospitalYoshihiro Fukumoto - Kurume UniversityTsutomu Imaizumi - Kurume University
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.78(9), pp.2284-U394
- DOI
- 10.1253/circj.CJ-14-0027
- PMID
- 24976508
- NLM abbreviation
- Circ J
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Publisher
- Japanese Circulation Soc
- Number of pages
- 9
- Grant note
- Ministry of Education, Culture, Sports, Science and Technology, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- Language
- English
- Date published
- 2014
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961026802771
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