Journal article
Large Blood Pressure Variability and Hypertensive Cardiac Remodeling - Role of Cardiac Inflammation
Circulation journal : official journal of the Japanese Circulation Society, Vol.73(12), pp.2198-2203
2009
DOI: 10.1253/circj.CJ-09-0741
PMID: 19875896
Abstract
An increase in short-term blood pressure (BP) variability is a characteristic feature of hypertensive patients, especially in elderly patients. There is increasing evidence that large BP variability aggravates hypertensive target organ damage and is an independent risk factor for the cardiovascular events in elderly hypertensive patients. However, little is known about the underlying mechanism. We have created a rat model of a combination of hypertension and large BP variability by performing sinoaortic denervation (SAD) in spontaneously hypertensive rats (SHRs). SAD aggravates left ventricular (LV)/triyocyte hypertrophy and myocardial fibrosis to a greater extent and impairs LV systolic function without changing mean BP in SHR. SAD upregulates cardiac monocyte chemoattractant protein-1 and transforming growth factor-beta, and induces macrophage infiltration. Cardiac angiotensinogen expression is increased and the angiotensin II type I receptor is activated by SAD. A subdepressor dose of angiotensin receptor blocker abolishes SAD-induced inflammatory changes and cardiac remodeling and subsequently prevents systolic dysfunction in SHR+SAD. Accordingly, it is suggested that cardiac inflammation via activation of the cardiac angiotensin II system Would play a role in the aggravation of cardiac remodeling and dysfunction in hypertensives with large BP variability. (Circ J 2009, 73: 2198-2203)
Details
- Title: Subtitle
- Large Blood Pressure Variability and Hypertensive Cardiac Remodeling - Role of Cardiac Inflammation
- Creators
- Hisashi Kai - Kurume UniversityHiroshi Kudo - Kurume UniversityNarimasa Takayama - Kurume UniversitySuguru Yasuoka - Kurume UniversityHidemi Kajimoto - Kurume UniversityTsutomu Imaizumi - Kurume University
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.73(12), pp.2198-2203
- DOI
- 10.1253/circj.CJ-09-0741
- PMID
- 19875896
- NLM abbreviation
- Circ J
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Publisher
- Japanese Circulation Soc
- Number of pages
- 6
- Grant note
- Kakihara Science Foundation Takeda Science Foundation; Takeda Science Foundation (TSF) Japan Society for the Promotion of Science, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science Ministry of Education, Culture, Sports, Science and Technology, Japan (Cardiovascular Research Institute); Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ishibashi Memorial Foundation Medical Care Education Research Foundation
- Language
- English
- Date published
- 2009
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961026602771
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