Journal article
Large-Scale Production of 119mTe and 119Sb for Radiopharmaceutical Applications
ACS central science, Vol.5(3), pp.494-505
03/27/2019
DOI: 10.1021/acscentsci.8b00869
PMCID: PMC6439462
PMID: 30937377
Abstract
Radionuclides find
widespread use in medical technologies for treating
and diagnosing disease. Among successful and emerging radiotherapeutics,
119
Sb has unique potential in targeted therapeutic applications
for low-energy electron-emitting isotopes. Unfortunately, developing
119
Sb-based drugs has been slow in comparison to other radionuclides,
primarily due to limited accessibility. Herein is a production method
that overcomes this challenge and expands the available time for large-scale
distribution and use. Our approach exploits high flux and fluence
from high-energy proton sources to produce longer lived
119m
Te. This parent isotope slowly decays to
119
Sb, which
in turn provides access to
119
Sb for longer time periods
(in comparison to direct
119
Sb production routes). We contribute
the target design, irradiation conditions, and a rapid procedure for
isolating the
119m
Te/
119
Sb pair. To guide process
development and to understand why the procedure was successful, we
characterized the Te/Sb separation using Te and Sb K-edge X-ray absorption
spectroscopy. The procedure provides low-volume aqueous solutions
that have high
119m
Te—and consequently
119
Sb—specific activity in a chemically pure form. This procedure
has been demonstrated at large-scale (production-sized, Ci quantities),
and the product has potential to meet stringent Food and Drug Administration
requirements for a
119m
Te/
119
Sb active pharmaceutical
ingredient.
A large-scale production
method for
119m
Te and
119
Sb from an Sb target
is described, with X-ray absorption
spectroscopy measurements providing insight into the success of the
chemical separations.
Details
- Title: Subtitle
- Large-Scale Production of 119mTe and 119Sb for Radiopharmaceutical Applications
- Creators
- Kevin T Bennett - Los Alamos National LaboratorySharon E Bone - Los Alamos National LaboratoryAndrew C Akin - Los Alamos National LaboratoryEva R Birnbaum - Los Alamos National LaboratoryAnastasia V Blake - Los Alamos National Laboratory University of IowaMark Brugh - Los Alamos National LaboratoryScott R Daly - University of IowaJonathan W Engle - Los Alamos National Laboratory University of WisconsinMichael E Fassbender - Los Alamos National LaboratoryMaryline G Ferrier - Los Alamos National LaboratoryStosh A Kozimor - Los Alamos National LaboratoryLaura M Lilley - Los Alamos National LaboratoryChristopher A Martinez - Los Alamos National LaboratoryVeronika Mocko - Los Alamos National LaboratoryFrancois M Nortier - Los Alamos National LaboratoryBenjamin W Stein - Los Alamos National LaboratorySara L Thiemann - Los Alamos National LaboratoryChristiaan Vermeulen - Los Alamos National Laboratory
- Resource Type
- Journal article
- Publication Details
- ACS central science, Vol.5(3), pp.494-505
- DOI
- 10.1021/acscentsci.8b00869
- PMID
- 30937377
- PMCID
- PMC6439462
- NLM abbreviation
- ACS Cent Sci
- ISSN
- 2374-7943
- eISSN
- 2374-7951
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100008902, name: Los Alamos National Laboratory; DOI: 10.13039/100006132, name: Office of Science
- Language
- English
- Date published
- 03/27/2019
- Academic Unit
- Chemistry
- Record Identifier
- 9984216682602771
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