Journal article
Large cell neuroendocrine carcinoma of the ovary: A pathologic entity in search of clinical identity
World journal of clinical oncology, Vol.5(2), pp.36-38
05/10/2014
DOI: 10.5306/wjco.v5.i2.36
PMCID: PMC4014794
PMID: 24829849
Abstract
Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare diagnosis and only a few dozen cases have been reported in the literature. It is characterized by large pleiomorphic cells with large round or oval nuclei, presence of mitoses and staining for neuroendocrine (NE) markers such as chromogranin A, synaptophysin, neuron specific enolase. This editorial gives a brief overview of this histologic type of ovarian carcinomas. LCNEC of the ovary is a pathologic entity that may not be diagnosed purely on clinical grounds due to the similarity of its clinical features with those of the more common epithelial ovarian cancers. Nevertheless the diagnosis is worth-making from a practical point of view in order to consider treatments tailored towards the NE component if it is dominant or it becomes dominant during the natural evolution of the disease. Establishment of an international tumor registry with an accompanying tumor tissue bank of ovarian LCNEC could be a means of obtaining further knowledge on clinical characteristics and advance research on this rare entity. This will further inform on treatment strategies and could identify future molecular treatment targets. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
Details
- Title: Subtitle
- Large cell neuroendocrine carcinoma of the ovary: A pathologic entity in search of clinical identity
- Creators
- Ioannis A. Voutsadakis - Sault Area Hosp, Div Med Oncol, 750 Great North Rd, Sault Ste Marie, ON P6B 0A8, Canada
- Resource Type
- Journal article
- Publication Details
- World journal of clinical oncology, Vol.5(2), pp.36-38
- DOI
- 10.5306/wjco.v5.i2.36
- PMID
- 24829849
- PMCID
- PMC4014794
- NLM abbreviation
- World J Clin Oncol
- ISSN
- 2218-4333
- eISSN
- 2218-4333
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 3
- Language
- English
- Date published
- 05/10/2014
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806506802771
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