Large-dose infusions of heparinoid ORG 10172 in ischemic stroke

E. W MASSEY; J BILLER; J. N DAVIS; H. P ADAMS; J. R MARLER; L. B GOLDSTEIN; M ALBERTS; A BRUNO

doi:10.1161/01.STR.21.9.1289

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Large-dose infusions of heparinoid ORG 10172 in ischemic stroke

Journal article

Open access

Peer reviewed

Large-dose infusions of heparinoid ORG 10172 in ischemic stroke

E. W MASSEY, J BILLER, J. N DAVIS, H. P ADAMS, J. R MARLER, L. B GOLDSTEIN, M ALBERTS and A BRUNO

Stroke (1970), Vol.21(9), pp.1289-1292

1990

DOI: 10.1161/01.STR.21.9.1289

PMID: 2396265

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Abstract

We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The plasma level of ORG 10172 was monitored by the degree of inhibition of coagulation factor Xa. In general, the drug was well tolerated and few hemorrhagic complications occurred. Two patients with large cardioembolic hemispheric strokes had intracranial hemorrhagic complications. Most patients improved during treatment. By 3 months after the stroke, 37 patients (65%) had a favorable outcome (minimal or no residual disability). This study suggests that high-dose intravenous infusions of ORG 10172 can be safely given to patients with acute ischemic stroke.

Biological and medical sciences

Medical sciences

Blood. Blood coagulation. Reticuloendothelial system

Pharmacology. Drug treatments

Details

Title: Subtitle: Large-dose infusions of heparinoid ORG 10172 in ischemic stroke
Creators: E. W MASSEY - Duke univ. medical cent., Durham NC 27710, United States
J BILLER - Duke univ. medical cent., Durham NC 27710, United States
J. N DAVIS - Duke univ. medical cent., Durham NC 27710, United States
H. P ADAMS - Duke univ. medical cent., Durham NC 27710, United States
J. R MARLER - Duke univ. medical cent., Durham NC 27710, United States
L. B GOLDSTEIN - Duke univ. medical cent., Durham NC 27710, United States
M ALBERTS - Duke univ. medical cent., Durham NC 27710, United States
A BRUNO - Duke univ. medical cent., Durham NC 27710, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.21(9), pp.1289-1292
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1161/01.STR.21.9.1289
PMID: 2396265
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 1990
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020892502771

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