Journal article
Large-vessel stenosis in the patients with ischemic stroke in Iran: Prevalence, pattern, and risk factors
Journal of vascular and interventional neurology, Vol.8(1), pp.11-16
02/2015
PMCID: PMC4367801
PMID: 25825626
Abstract
Large artery disease (LAD) is a common cause of stroke, but a little is known regarding its role in Iranian stroke patients. The current study investigates the prevalence and risk factors for cervicocephalic arterial stenosis in the patients with ischemic stroke using digital subtraction angiography (DSA).
This was a prospective cross-sectional study performed in hospitals affiliated to Shiraz University of Medical Sciences from March 2011 to March 2013. Patients with ischemic stroke underwent noninvasive vascular and cardiac investigations to find the etiology of the stroke. Patients suspected of having large artery stenosis underwent DSA. The severity of the stenosis was calculated according to the North American Symptomatic Carotid Endarterectomy (NASCET) and Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial criteria. The presence of cigarette smoking, hyperlipidemia, hypertension, and diabetes mellitus were documented for all subjects.
A total of 3703 stroke patients were identified. Of them, 342 patients (62.3%, male) underwent DSA for LAD. The mean age at the time of angiography was 66.7±10.3 years. Extracranial and intracranial arteries were involved in 305 (89.2%) and 162 (47.4%), respectively. And 301 patients (88%) had anterior circulation and 128 patients (37.4%) had posterior circulation involvement. Diabetes mellitus but not age, sex, hypertension, hyperlipidemia, or smoking was significantly associated with intracranial involvement. (P = 0.002).
It can be concluded that the distribution of the large arterial atherosclerotic disease in Iran is similar to that seen in North America and Europe. Intracranial stenosis was more prevalent in diabetic patients.
Details
- Title: Subtitle
- Large-vessel stenosis in the patients with ischemic stroke in Iran: Prevalence, pattern, and risk factors
- Creators
- Afshin Borhani-HaghighiMehrdad Emami - Shiraz University of Medical SciencesAmin Sadeghi Vasaksi - Shiraz University of Medical SciencesAbdolhamid Shariat - Shiraz University of Medical SciencesMohammad Amin Banihashemi - Shiraz University of Medical SciencesAlireza Nikseresht - Shiraz University of Medical SciencesNahid Ashjazadeh - Shiraz University of Medical SciencesSadegh Izadi - Shiraz University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesMaryam Poursadegh - Shiraz University of Medical SciencesAbbas Rahimi Jaberi - Shiraz University of Medical SciencesSajjad Emami - Jahrom University of Medical SciencesHamid Agheli - Neurologist, Shahidzadeh Hospital, Behbahan, IranReza Nemati - Bushehr University of Medical SciencesEhsan Yaghoubi - Yasuj University of Medical SciencesMohammad Hosein Abdi - Neurologist, Motaharri Hospital, Marvdasht, IranMohammad Mohammadi - Neurologist, NIOC Hospital, Gachsaran, IranPeyman Jafari - Shiraz University of Medical SciencesSalvador Cruz-Flores - Departments of Neurology, Texas Tech University, El Paso, USARandal Edgell - Departments of Neurology and Psychiatry , Saint Louis University, Saint Louis, USA
- Resource Type
- Journal article
- Publication Details
- Journal of vascular and interventional neurology, Vol.8(1), pp.11-16
- PMID
- 25825626
- PMCID
- PMC4367801
- NLM abbreviation
- J Vasc Interv Neurol
- ISSN
- 1941-5893
- eISSN
- 1944-141X
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Neurology
- Record Identifier
- 9985014705202771
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