Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage

Paul Escher; Lihong Bu; Zuzan Cayci; Bevan Yueh; Faqian Li

doi:10.1007/s12105-019-01119-w

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Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage

Journal article

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Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage

Paul Escher, Lihong Bu, Zuzan Cayci, Bevan Yueh and Faqian Li

Head & neck pathology (Totowa, N.J.), Vol.14(3), pp.771-777

09/01/2020

DOI: 10.1007/s12105-019-01119-w

PMCID: PMC7413955

PMID: 31873935

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https://www.ncbi.nlm.nih.gov/pmc/articles/7413955View

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Abstract

Basaloid squamous cell carcinoma (BSCC) with a spindle cell component of the head and neck is an uncommon entity. In this case, we present a radiology–pathology correlation of a rare laryngeal BSCC with sarcomatous transformation and osteosarcomatous differentiation involving the laryngeal cartilage, which thus mimicked clinically and radiographically osteosarcoma or chondrosarcoma with calcification. Microscopic examination revealed predominantly BSCC with extensive osseous metaplasia among sheets and nests of basaloid tumor cells. There were also small foci of osteosarcoma, undifferentiated pleomorphic sarcoma, and spindle cell carcinoma. The presence of squamous cell carcinoma (SCC) in-situ, small areas of conventional SCC and diffuse positivity of p40 in conventional and basaloid squamous components confirmed that this tumor was indeed derived from surface squamous epithelium. Awareness of the broad differentiation potentials of SCC can avoid misdiagnosis of SCCs as sarcoma. This case emphasizes the importance of radiologic–pathologic correlation in definitive diagnosis and clinical management of laryngeal malignancies.

Sine qua non Radiology-Pathology

Details

Title: Subtitle: Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage
Creators: Paul Escher - Minneapolis, MN USA
Lihong Bu - MMC 76, C476 Mayo Building, 420 Delaware St. SE, Minneapolis, MN 55455 USA
Zuzan Cayci - Minneapolis, MN USA
Bevan Yueh - Minneapolis, MN USA
Faqian Li - MMC 76, C476 Mayo Building, 420 Delaware St. SE, Minneapolis, MN 55455 USA
Resource Type: Journal article
Publication Details: Head & neck pathology (Totowa, N.J.), Vol.14(3), pp.771-777
DOI: 10.1007/s12105-019-01119-w
PMID: 31873935
PMCID: PMC7413955
NLM abbreviation: Head Neck Pathol
ISSN: 1936-055X
eISSN: 1936-0568
Publisher: Springer US
Number of pages: 7
Language: English
Date published: 09/01/2020
Academic Unit: Otolaryngology
Record Identifier: 9984966745902771

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