Lassa Fever Virus Binds Matriglycan—A Polymer of Alternating Xylose and Glucuronate—On α-Dystroglycan

Soumya Joseph; Kevin P. Campbell

doi:10.3390/v13091679

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Lassa Fever Virus Binds Matriglycan—A Polymer of Alternating Xylose and Glucuronate—On α-Dystroglycan

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Lassa Fever Virus Binds Matriglycan—A Polymer of Alternating Xylose and Glucuronate—On α-Dystroglycan

Soumya Joseph and Kevin P. Campbell

Viruses, Vol.13(1679), p.1679

08/01/2021

DOI: 10.3390/v13091679

PMCID: PMC8473316

PMID: 34578260

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Abstract

Lassa fever virus (LASV) can cause life-threatening hemorrhagic fevers for which there are currently no vaccines or targeted treatments. The late Prof. Stefan Kunz, along with others, showed that the high-affinity host receptor for LASV, and other Old World and clade-C New World mammarenaviruses, is matriglycan—a linear repeating disaccharide of alternating xylose and glucuronic acid that is polymerized uniquely on α-dystroglycan by like-acetylglucosaminyltransferase-1 (LARGE1). Although α-dystroglycan is ubiquitously expressed, LASV preferentially infects vascular endothelia and professional phagocytic cells, which suggests that viral entry requires additional cell-specific factors. In this review, we highlight the work of Stefan Kunz detailing the molecular mechanism of LASV binding and discuss the requirements of receptors, such as tyrosine kinases, for internalization through apoptotic mimicry.

Axl

Gas6

Lassa fever virus

lymphocytic choriomeningitis

matriglycan

α-dystroglycan

Details

Title: Subtitle: Lassa Fever Virus Binds Matriglycan—A Polymer of Alternating Xylose and Glucuronate—On α-Dystroglycan
Creators: Soumya Joseph - Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Kevin P. Campbell - Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Viruses, Vol.13(1679), p.1679
DOI: 10.3390/v13091679
PMID: 34578260
PMCID: PMC8473316
NLM abbreviation: Viruses
eISSN: 1999-4915
Publisher: MDPI AG
Grant note: name: Paul D. Wellstone Muscular Dystrophy Specialized Research Center grant, award: 1U54NS053672; DOI: 10.13039/100000011, name: Howard Hughes Medical Institute, award: n/a
Language: English
Date published: 08/01/2021
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984172168002771

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