Journal article
Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease
Psychological medicine, Vol.52(15), pp.1-10
11/01/2022
DOI: 10.1017/S0033291721000416
PMID: 33849668
Abstract
Background: Cynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD.Methods: In community-dwelling older adults from the French ESPRIT cohort (n = 1388), incident dementia rate according to CH level was monitored during an 8-year follow-up and analyzed using Cox proportional hazards regression models. Brain magnetic resonance imaging volumes were measured at baseline (n = 508). Using automated segmentation procedures (Freesurfer 6.0), the authors assessed brain grey and white volumes on all magnetic resonance imaging scans. They also measured white matter hyperintensities volumes using semi-automated procedures. Mean volumes according to the level of CH were compared using ANOVA.Results: Eighty-four participants developed dementia (32 with AD). After controlling for potential confounders, high CH was predictive of AD (HR 2.74; 95% CI 1.10-6.85; p = 0.030) and all dementia types are taken together (HR 2.30; 95% CI 1.10-4.80; p = 0.027). High CH was associated with white matter alterations, particularly smaller anterior corpus callosum volume (p < 0.01) after False Discovery Rate correction, but not with grey matter volumes.Conclusions: High CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies.
Details
- Title: Subtitle
- Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease
- Creators
- Fabienne Cyprien - Institut de Génomique FonctionnelleClaudine Berr - Institute for Neurosciences of MontpellierJerome Maller - Melbourne Medical School [Melbourne]Chantal Meslin - Australian National UniversityMélissa Gentreau - Institut de Génomique FonctionnelleThibault Mura - Institute for Neurosciences of MontpellierAudrey Gabelle - Institute for Neurosciences of MontpellierPhilippe Courtet - Institut de Génomique FonctionnelleKaren Ritchie - University of EdinburghMarie-Laure Ancelin - Institut des Neurosciences de MontpellierSylvaine Artero - Institut de Génomique Fonctionnelle
- Resource Type
- Journal article
- Publication Details
- Psychological medicine, Vol.52(15), pp.1-10
- DOI
- 10.1017/S0033291721000416
- PMID
- 33849668
- NLM abbreviation
- Psychol Med
- ISSN
- 0033-2917
- eISSN
- 1469-8978
- Publisher
- Cambridge University Press (CUP)
- Number of pages
- 10
- Language
- English
- Date published
- 11/01/2022
- Academic Unit
- Radiology
- Record Identifier
- 9984848506302771
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