Journal article
Late-onset Sepsis in Extremely Premature Infants 2000-2011
The Pediatric infectious disease journal, Vol.36(8), pp.774-779
08/01/2017
DOI: 10.1097/INF.0000000000001570
PMCID: PMC5627954
PMID: 28709162
Abstract
Background: Late-onset sepsis (LOS) is an important cause of death and neurodevelopmental impairment in premature infants. The purpose of this study was to assess overall incidence of LOS, distribution of LOS-causative organisms and center variation in incidence of LOS for extremely premature infants over time.
Methods: In a retrospective analysis of infants 401-1000 g birth weight and 22-28 6/7 weeks of gestational age born at 12 National Institute of Child Health and Human Development Neonatal Research Network centers in the years 2000-2005 (era 1) or 2006-2011 (era 2) who survived >72 hours,we compared the incidence of LOS and pathogen distribution in the 2 eras using the chi(2) test. We also examined the effect of birth year on the incidence of LOS using multivariable regression to adjust for nonmodifiable risk factors and for center. To assess whether the incidence of LOS was different among centers in era 2, we used a multivariable regression model to adjust for nonmodifiable risk factors.
Results: Ten-thousand one-hundred thirty-one infants were studied. LOS occurred in 2083 of 5031 (41%) infants in era 1 and 1728 of 5100 (34%) infants in era 2 (P < 0.001). Birth year was a significant predictor of LOS on adjusted analysis, with birth years 2000-2009 having a significantly higher odds of LOS than the reference year 2011. Pathogens did not differ, with the exception of decreased fungal infection (P < 0.001). In era 2, 9 centers had significantly higher odds of LOS compared with the center with the lowest incidence.
Conclusions: The incidence of LOS decreased over time. Further investigation is warranted to determine which interventions have the greatest impact on infection rates.
Details
- Title: Subtitle
- Late-onset Sepsis in Extremely Premature Infants 2000-2011
- Creators
- Rachel G. Greenberg - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSarah Kandefer - RTI (United States)Barbara T. Do - RTI (United States)P. Brian Smith - Duke UniversityBarbara J. Stoll - Emory UniversityEdward F. Bell - Univ Iowa, Dept Pediat, Iowa City, IA 52242 USAWaldemar A. Carlo - University of AlabamaAbbot R. Laptook - Brown UniversityPablo J. Sanchez - The University of Texas Southwestern Medical CenterSeetha Shankaran - Wayne State UniversityKrisa P. Van MeursM. Bethany Ball - Stanford UniversityEllen C. Hale - Emory UniversityNancy S. Newman - Case Western Reserve UniversityAbhik Das - RTI Int, Social Stat & Environm Sci Unit, Rockville, MD USARosemary D. Higgins - Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USAC. Michael Cotten - Duke UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Pediatric infectious disease journal, Vol.36(8), pp.774-779
- DOI
- 10.1097/INF.0000000000001570
- PMID
- 28709162
- PMCID
- PMC5627954
- NLM abbreviation
- Pediatr Infect Dis J
- ISSN
- 0891-3668
- eISSN
- 1532-0987
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA HHS0100201300009C / Cempra Pharmaceuticals 5T32HD043728-10 / NIH training grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA industry for neonatal and pediatric drug development National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UG1HD027880 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) 1R18-FD005292-01 / Food and Drug Administration; United States Department of Health & Human Services R18FD005292 / FOOD AND DRUG ADMINISTRATION; United States Department of Health & Human Services HHSN275201000003I; 1R01-HD081044-01 / NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) DHHS-1R18AE000028-01 / US Department of Health and Human Services UL1TR001117 / National Center for Advancing Translational Sciences of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UL1TR001117 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354049702771
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