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Late onset imatinib-induced Stevens-Johnson syndrome
Journal article   Peer reviewed

Late onset imatinib-induced Stevens-Johnson syndrome

Evan Bois, Lisa M Holle and Umar Farooq
Journal of oncology pharmacy practice, Vol.20(6), pp.476-478
12/2014
DOI: 10.1177/1078155213518226
PMID: 24399835

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Abstract

Imatinib, a BCR-ABL tyrosine kinase inhibitor, is known to cause mild to moderate cutaneous reactions in up to approximately 20% of patients. It rarely causes severe reactions, such as Stevens-Johnson syndrome, which can be life threatening. Typically, these rashes occur within two months of initiating therapy. We report a case of Stevens-Johnson syndrome induced by imatinib after several years of therapy, but later successfully was treated with nilotinib therapy.
Piperazines - administration & dosage Pyrimidines - administration & dosage Humans Stevens-Johnson Syndrome - etiology Male Antineoplastic Agents - administration & dosage Imatinib Mesylate Piperazines - adverse effects Young Adult Benzamides - administration & dosage Time Factors Antineoplastic Agents - adverse effects Pyrimidines - therapeutic use Pyrimidines - adverse effects Benzamides - adverse effects

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