Late postnatal transmission of HIV-1 and associated factors

Taha E Taha; Donald R Hoover; Newton I Kumwenda; Susan A Fiscus; George Kafulafula; Chiwawa Nkhoma; Shu Chen; Estelle Piwowar; Robin L Broadhead; J Brooks Jackson; Paolo G Miotti

doi:10.1086/518511

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Late postnatal transmission of HIV-1 and associated factors

Journal article

Open access

Peer reviewed

Late postnatal transmission of HIV-1 and associated factors

Taha E Taha, Donald R Hoover, Newton I Kumwenda, Susan A Fiscus, George Kafulafula, Chiwawa Nkhoma, Shu Chen, Estelle Piwowar, Robin L Broadhead, J Brooks Jackson, …

The Journal of infectious diseases, Vol.196(1), pp.10-14

07/01/2007

DOI: 10.1086/518511

PMID: 17538877

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Abstract

The present study was undertaken to determine the risk and timing of late postnatal transmission (LPT) of human immunodeficiency virus type 1 (HIV-1). Breast-fed infants previously enrolled in 2 trials of antiretroviral prophylaxis were monitored in Malawi. Kaplan-Meier and proportional hazard models assessed cumulative incidence and association of factors with LPT. Overall, 98 infants were HIV infected, and 1158 were uninfected. The cumulative risk of LPT at age 24 months was 9.68% (95% confidence interval, 7.80%-11.56%). The interval hazards at 1.5-6, 6-12, 12-18, and 18-24 months were 1.22%, 4.05%, 3.48%, and 1.27%, respectively. The risk of LPT beyond 6 months is substantial. Weaning at 6 months could prevent >85% of LPT.

Breast Feeding

Malawi

Follow-Up Studies

HIV Infections - epidemiology

Humans

Risk Factors

RNA, Viral - analysis

Infant

Nevirapine - therapeutic use

Infectious Disease Transmission, Vertical

Milk, Human - virology

Incidence

Time Factors

HIV-1 - isolation & purification

Female

HIV Infections - transmission

Zidovudine - therapeutic use

Infant, Newborn

Details

Title: Subtitle: Late postnatal transmission of HIV-1 and associated factors
Creators: Taha E Taha - Department of Epidemiology, Bloomberg School of Public Health, Baltimore, MD 21205, USA. ttaha@jhsph.edu
Donald R Hoover
Newton I Kumwenda
Susan A Fiscus
George Kafulafula
Chiwawa Nkhoma
Shu Chen
Estelle Piwowar
Robin L Broadhead
J Brooks Jackson
Paolo G Miotti
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.196(1), pp.10-14
DOI: 10.1086/518511
PMID: 17538877
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: United States
Grant note: U01 AI068613 / NIAID NIH HHS U01 AI48005 / NIAID NIH HHS U01 AI068613-02 / NIAID NIH HHS 5 R03 TW01199 / FIC NIH HHS
Language: English
Date published: 07/01/2007
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047690202771

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