Journal article
Lateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.270(1), pp.R162-R168
01/01/1996
DOI: 10.1152/ajpregu.1996.270.1.R162
PMID: 8769798
Abstract
This study investigated the effects of bilateral injections of serotonergic receptor agonist and antagonist into the lateral parabrachial nucleus (LPBN) on the ingestion of water and 0.3 M NaCl induced by intracerebroventricular angiotensin II (ANG II) or by combined subcutaneous injections of the diuretic furosemide (Furo) and the angiotensin-converting enzyme inhibitor captopril (Cap). Rats had stainless steel cannulas implanted bilaterally into the LPBN and into the left lateral ventricle. Bilateral LPBN pretreatment with the serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (4 micrograms/200 nl each site) increased 0.3 M NaCl and water intakes induced by intracerebroventricular ANG II (50 ng/microliter) and 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with bilateral LPBN injections of a serotonergic 5-HT2A/2C receptor agonist DOI (5 micrograms/200 nl) significantly reduced 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with methysergide or DOI into the LPBN produced no significant changes in the water intake induced by subcutaneous Furo + Cap. These results suggest that serotonergic mechanisms associated with the LPBN may have inhibitory roles in water and sodium ingestion in rats.
Details
- Title: Subtitle
- Lateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in rats
- Creators
- Jose Vanderlei Menani - Department of Psychology, University of Iowa, Iowa City 52242-1407, USARobert L Thunhorst - Department of Psychology, University of Iowa, Iowa City 52242-1407, USAAlan Kim Johnson - Department of Psychology, University of Iowa, Iowa City 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.270(1), pp.R162-R168
- DOI
- 10.1152/ajpregu.1996.270.1.R162
- PMID
- 8769798
- NLM abbreviation
- Am J Physiol Regul Integr Comp Physiol
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 01/01/1996
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213431502771
Metrics
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