Journal article
Lateral parabrachial nucleus modulates baroreflex regulation of sympathetic nerve activity
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(5), pp.R1274-R1282
05/01/1998
DOI: 10.1152/ajpregu.1998.274.5.R1274
PMID: 9644040
Abstract
Previous studies have demonstrated that the lateral parabrachial nucleus (LPBN) is an important site for descending modulation of baroreflex control of heart rate. In the present study it was hypothesized that the LPBN neurons may also modulate baroreflex control of arterial pressure and sympathetic nerve activity. In urethan-anesthetized rats, electrical or chemical activation of the LPBN produced a significant reduction in the magnitude of the baroreflex inhibition of mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) elicited by aortic depressor nerve stimulation. Chemical inactivation of the LPBN resulted in a small increase in baroreflex control of MAP, but baroreflex control of RSNA was not affected. The results suggest that LPBN neurons have little tonic influence over baroreflex control of MAP and RSNA in the anesthetized rat. When the LPBN is activated, however, LPBN neurons may function to reduce the capacity of the baroreflex to regulate sympathetically mediated increases in arterial pressure.
Details
- Title: Subtitle
- Lateral parabrachial nucleus modulates baroreflex regulation of sympathetic nerve activity
- Creators
- Linda F Hayward - Cardiovascular Center and Department of Internal Medicine, University of Iowa College of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242Robert B Felder - Cardiovascular Center and Department of Internal Medicine, University of Iowa College of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(5), pp.R1274-R1282
- DOI
- 10.1152/ajpregu.1998.274.5.R1274
- PMID
- 9644040
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 05/01/1998
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065378802771
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