Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion

José Vanderlei Menani; Laurival Antonio De Luca; Alan Kim Johnson

doi:10.1152/ajpregu.1998.274.2.R555

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Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion

Journal article

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Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion

José Vanderlei Menani, Laurival Antonio De Luca and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(2), pp.R555-R560

02/01/1998

DOI: 10.1152/ajpregu.1998.274.2.R555

PMID: 9486317

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Abstract

This study investigated the effects of bilateral injections of a serotonin (5-HT) receptor agonist into the lateral parabrachial nucleus (LPBN) on the intake of NaCl and water induced by 24-h water deprivation or by sodium depletion followed by 24 h of sodium deprivation (injection of the diuretic furosemide plus 24 h of sodium-deficient diet). Rats had stainless steel cannulas implanted bilaterally into the LPBN. Bilateral LPBN injections of the serotonergic 5-HT1/2 receptor antagonist methysergide (4 μg/200 nl at each site) increased hypertonic NaCl intake when tested 24 h after sodium depletion and after 24 h of water deprivation. Water intake also increased after bilateral injections of methysergide into the LPBN. In contrast, the intake of a palatable solution (0.06 M sucrose) under body fluid-replete conditions was not changed after bilateral LPBN methysergide injections. The results show that serotonergic mechanisms in the LPBN modulate water and sodium intake induced by volume depletion and sodium loss. The finding that sucrose intake was not affected by LPBN serotonergic blockade suggests that the effects of the methysergide treatment on the intakes of water and NaCl are not due to a mechanism producing a nonspecific enhancement of all ingestive behaviors.

Details

Title: Subtitle: Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion
Creators: José Vanderlei Menani - Department of Physiology, School of Dentistry, Paulista State University, Araraquara, São Paulo 14801–903, Brazil; and
Laurival Antonio De Luca - Department of Physiology, School of Dentistry, Paulista State University, Araraquara, São Paulo 14801–903, Brazil; and
Alan Kim Johnson - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242–1407
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(2), pp.R555-R560
DOI: 10.1152/ajpregu.1998.274.2.R555
PMID: 9486317
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Language: English
Date published: 02/01/1998
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213414502771

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