Journal article
Lead exposure and serum metabolite profiles in pregnant women in Mexico City
Environmental health, Vol.20(1), pp.125-125
12/10/2021
DOI: 10.1186/s12940-021-00810-2
PMCID: PMC8665540
PMID: 34893088
Abstract
Background Lead (Pb) exposure is a global health hazard causing a wide range of adverse health outcomes. Yet, the mechanisms of Pb toxicology remain incompletely understood, especially during pregnancy. To uncover biological pathways impacted by Pb exposure, this study investigated serum metabolomic profiles during the third trimester of pregnancy that are associated with blood Pb and bone Pb. Methods We used data and specimens from 99 women enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors birth cohort in Mexico City. Maternal Pb exposure was measured in whole blood samples from the third trimester of pregnancy and in the tibia and patella bones at 1 month postpartum. Third-trimester serum samples underwent metabolomic analysis; metabolites were identified based on matching to an in-house analytical standard library. A metabolome-wide association study was performed using multiple linear regression models. Class- and pathway-based enrichment analyses were also conducted. Results The median (interquartile range) blood Pb concentration was 2.9 (2.6) mu g/dL. Median bone Pb, measured in the tibia and patella, were 2.5 (7.3) mu g/g and 3.6 (9.5) mu g/g, respectively. Of 215 total metabolites identified in serum, 31 were associated with blood Pb (p < 0.05). Class enrichment analysis identified significant overrepresentation of metabolites classified as fatty acids and conjugates, amino acids and peptides, and purines. Tibia and patella Pb were associated with 14 and 8 metabolites, respectively (p < 0.05). Comparing results from bone and blood Pb, glycochenodeoxycholic acid, glycocholic acid, and 1-arachidonoylglycerol were positively associated with blood Pb and tibia Pb, and 7-methylguanine was negatively associated with blood Pb and patella Pb. One metabolite, 5-aminopentanoic acid, was negatively associated with all three Pb measures. Conclusions This study identified serum metabolites in pregnant women associated with Pb measured in blood and bone. These findings provide insights on the metabolic profile around Pb exposure in pregnancy and information to guide mechanistic studies of toxicological effects for mothers and children.
Details
- Title: Subtitle
- Lead exposure and serum metabolite profiles in pregnant women in Mexico City
- Creators
- Megan M. Niedzwiecki - Icahn School of Medicine at Mount SinaiShoshannah Eggers - Icahn School of Medicine at Mount SinaiAnu Joshi - Icahn School of Medicine at Mount SinaiGeorgia Dolios - Icahn School of Medicine at Mount SinaiAlejandra Cantoral - Ibero American UniversityHector Lamadrid-Figueroa - Instituto Nacional de Salud PúblicaChitra Amarasiriwardena - Icahn School of Medicine at Mount SinaiMartha M. Tellez-Rojo - Instituto Nacional de Salud PúblicaRobert O. Wright - Icahn School of Medicine at Mount SinaiLauren Petrick - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- Environmental health, Vol.20(1), pp.125-125
- DOI
- 10.1186/s12940-021-00810-2
- PMID
- 34893088
- PMCID
- PMC8665540
- NLM abbreviation
- Environ Health
- ISSN
- 1476-069X
- eISSN
- 1476-069X
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R01 ES014930; R01 ES013744; P30 ES023515; U2CES030859; T32 HD049311; R01 ES031117; R21 ES030882 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute of Public Health/Ministry of Health of Mexico
- Language
- English
- Date published
- 12/10/2021
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984446438002771
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