Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus

Hanna E Stevens; Ginger Y Jiang; Michael L Schwartz; Flora M Vaccarino

doi:10.1016/j.biopsych.2012.03.013

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Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus

Journal article

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Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus

Hanna E Stevens, Ginger Y Jiang, Michael L Schwartz and Flora M Vaccarino

Biological psychiatry (1969), Vol.71(12), pp.1090-1098

06/15/2012

DOI: 10.1016/j.biopsych.2012.03.013

PMCID: PMC3371339

PMID: 22541947

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https://www.ncbi.nlm.nih.gov/pmc/articles/3371339View

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Abstract

Fibroblast growth factor (FGF) signaling controls self-renewal of neural stem cells during embryonic telencephalic development. FGF receptor 2 (FGFR2) has a significant role in the production of cortical neurons during embryogenesis, but its role in the hippocampus during development and in adulthood has not been described. Here we dissociate the role of FGFR2 in the hippocampus during development and during adulthood with the use of embryonic knockout and inducible knockout mice. Embryonic knockout of FGFR2 causes a reduction of hippocampal volume and impairment in adult spatial memory in mice. Spatial reference memory, as assessed by performance on the water maze probe trial, was correlated with reduced hippocampal parvalbumin+ cells, whereas short-term learning was correlated with reduction in immature neurons in the dentate gyrus. Furthermore, short-term learning and newly generated neurons in the dentate gyrus were deficient even when FGFR2 was lacking only in adulthood. Taken together, these findings support a dual role for FGFR2 in hippocampal short-term learning and long-term reference memory, which appear to depend on the abundance of two separate cellular components, parvalbumin interneurons and newly generated granule cells in the hippocampus.

Neurogenesis

FGF receptor 2

learning

memory

hippocampus

parvalbumin

Details

Title: Subtitle: Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Creators: Hanna E Stevens - Child Study Center, Yale University, New Haven, Connecticut
Ginger Y Jiang - Child Study Center, Yale University, New Haven, Connecticut
Michael L Schwartz - Department of Neurobiology, Yale University, New Haven, Connecticut
Flora M Vaccarino - Child Study Center, Yale University, New Haven, Connecticut
Resource Type: Journal article
Publication Details: Biological psychiatry (1969), Vol.71(12), pp.1090-1098
DOI: 10.1016/j.biopsych.2012.03.013
PMID: 22541947
PMCID: PMC3371339
NLM abbreviation: Biol Psychiatry
ISSN: 0006-3223
eISSN: 1873-2402
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes Health, award: R01 MH067715, K08 MH086812-1, T32 MH018268, R25 MH071584, R25 MH077823
Language: English
Date published: 06/15/2012
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984070697402771

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