Journal article
Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
eLife, Vol.6, e27872
09/20/2017
DOI: 10.7554/eLife.27872
PMCID: PMC5606845
PMID: 28927503
Abstract
Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activated synapses. We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs targeting the activin A receptor type 1C (ACVR1C), a component of the transforming growth factor-β receptor superfamily. Furthermore, the absence of translin/trax abolishes synaptic upregulation of ACVR1C protein after learning. Finally, synaptic tagging and long-term memory deficits in mice lacking translin/trax are mimicked by ACVR1C inhibition. Thus, we define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
Details
- Title: Subtitle
- Learning induces the translin/trax RNase complex to express activin receptors for persistent memory
- Creators
- Alan Jung Park - Department of Biology, University of Pennsylvania, Philadelphia, United StatesRobbert Havekes - Department of Biology, University of Pennsylvania, Philadelphia, United StatesXiuping Fu - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesRolf Hansen - Department of Biology, University of Pennsylvania, Philadelphia, United StatesJennifer C Tudor - Department of Biology, University of Pennsylvania, Philadelphia, United StatesLucia Peixoto - Department of Biology, University of Pennsylvania, Philadelphia, United StatesZhi Li - Johns Hopkins University School of MedicineYen-Ching Wu - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesShane G Poplawski - Department of Biology, University of Pennsylvania, Philadelphia, United StatesJay M Baraban - Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesTed Abel - Molecular Physiology and Biophysics, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.6, e27872
- DOI
- 10.7554/eLife.27872
- PMID
- 28927503
- PMCID
- PMC5606845
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Publisher
- England
- Grant note
- P50 DA000266 / NIDA NIH HHS R01 MH087463 / NIMH NIH HHS
- Language
- English
- Date published
- 09/20/2017
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984024539302771
Metrics
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