Journal article
Learning-related neuronal activity in the ventral lateral geniculate nucleus during associative cerebellar learning
Journal of neurophysiology, Vol.112(9), pp.2234-2250
11/01/2014
DOI: 10.1152/jn.00185.2013
PMCID: PMC4274918
PMID: 25122718
Abstract
During delay eyeblink conditioning, rats learn to produce an eyelid-closure conditioned response (CR) to a conditioned stimulus (CS), such as a light, which precedes and coterminates with an unconditioned stimulus (US). Previous studies have suggested that the ventral lateral geniculate nucleus (LGNv) might play an important role in visual eyeblink conditioning by supplying visual sensory input to the pontine nuclei (PN) and also receiving feedback from the cerebellum. No prior study has investigated LGNv neuronal activity during eyeblink conditioning. The present study used multiple tetrodes to monitor single-unit activity in the rat LGNv during pre-exposure (CS only), unpaired CS/US, and paired CS-US training conditions. This behavioral-training sequence was used to investigate nonassociative- and associative-driven neuronal activity in the LGNv during training. LGNv neuronal activity habituated during unpaired training and then recovered from habituation during subsequent paired training, which may indicate that the LGNv plays a role in attention to the CS. The amplitude of LGNv neuronal activity correlated with CR production during paired but not unpaired CS/US training. Cerebellar feedback to the LGNv may play a role in modulating LGNv activity and attention to the CS during paired training. Based on the present findings, we hypothesize that the role of LGNv in visual eyeblink conditioning goes beyond simply routing visual CS information to the PN and involves modulation of attention.
Details
- Title: Subtitle
- Learning-related neuronal activity in the ventral lateral geniculate nucleus during associative cerebellar learning
- Creators
- Alireza Kashef - Department of Psychology, University of Iowa, Iowa City, Iowa; andMatthew M Campolattaro - Department of Psychology, Christopher Newport University, Newport News, VirginiaJohn H Freeman - Department of Psychology, University of Iowa, Iowa City, Iowa; and john-freeman@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Journal of neurophysiology, Vol.112(9), pp.2234-2250
- Publisher
- United States
- DOI
- 10.1152/jn.00185.2013
- PMID
- 25122718
- PMCID
- PMC4274918
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- Grant note
- MH080005 / NIMH NIH HHS
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065754202771
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