Journal article
Left atrial volume predicts atrial fibrillation recurrence after radiofrequency ablation: a meta-analysis
Europace (London, England), Vol.20(1), pp.33-42
01/01/2018
DOI: 10.1093/europace/eux013
PMID: 28444307
Abstract
Aims Left atrial (LA) diameter is a predictor of atrial fibrillation (AF) recurrence following radiofrequency catheter ablation (RFA). However, LA volume (LAV) is more accurate in assessing LA size. Studies evaluating LAV as a predictor of AF recurrence are contradictory; therefore, we performed a meta-analysis to assess whether LAV is an independent predictor of AF recurrence following RFA.
Methods and results All studies reporting LAV/LAV index (LAVi) as a predictor of AF recurrence following RFA were included. For studies reporting mean LAV/LAVi in patients with and without AF recurrence, standard difference in means (SDM) and standard errors were calculated, and combined using meta-analytical techniques. For studies reporting adjusted odds ratio (OR) for AF recurrence based on LAV/LAVi, log ORs were combined using generic inverse variance. Twenty one studies (3822 subjects) were included. Meta-analysis of 11 studies (1559 subjects) reporting LAV, showed that patients with AF recurrence had a higher mean LA volume compared to patients with no recurrence (SDM 0.801; CI 0.387-1.216). Data from 9 studies (1425 subjects) comparing LAVi showed that, patients with AF recurrence had a higher mean LAVi compared to patients with no recurrence (SDM-0.596; CI 0.305-0.888). Thirteen studies (2886 patients) reporting ORs for AF recurrence based on LAV/ LAVi, showed that LAV/LAVi was independently predictive of AF recurrence post-RFA (OR-1.032, CI- 1.012-1.052).
Conclusions Patients with AF recurrence following RFA have a higher mean LAV/LAVi compared to patients with no recurrence. Large LAV/LAVi increases the odds of AF recurrence post RFA.
Details
- Title: Subtitle
- Left atrial volume predicts atrial fibrillation recurrence after radiofrequency ablation: a meta-analysis
- Creators
- Augustine Njoku - Louisiana State University Health Sciences Center ShreveportMunish Kannabhiran - Louisiana State University Health Sciences Center ShreveportRishi Arora - Louisiana State University Health Sciences Center ShreveportPratap Reddy - Louisiana State University Health Sciences Center ShreveportRakesh Gopinathannair - University of LouisvilleDhanunjaya Lakkireddy - Center for Excellence in EducationPaari Dominic - Louisiana State University Health Sciences Center Shreveport
- Resource Type
- Journal article
- Publication Details
- Europace (London, England), Vol.20(1), pp.33-42
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/europace/eux013
- PMID
- 28444307
- ISSN
- 1099-5129
- eISSN
- 1532-2092
- Number of pages
- 10
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367125502771
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