Journal article
Left ventricular hypertrophy induced by overnutrition early in life
Nutrition, metabolism, and cardiovascular diseases, Vol.19(11), pp.805-810
12/01/2009
DOI: 10.1016/j.numecd.2009.01.008
PMID: 19359151
Abstract
Human overnutrition has caused a rise in the prevalence of obesity in recent years. In addition to the deleterious effects of obesity during childhood, the long-term effects in adulthood have also been described. For instance, cardiovascular diseases, particularly left ventricular hypertrophy, and type 2 diabetes are among the diseases associated with a history of obesity. However, it remains uncertain during which period of life this association is established. Several authors have suggested that the early period of life is critical for the emergence of cardiac disorders.
In this study, we examined the impact of overnutrition on the heart morphology and stereology of obese animals using an experimental model to induce an overweight phenotype. In these animals, overfeeding during lactation was able to induce a significant increase in body weight and visceral fat starting at the 10th day of life, and this increased weight persisted until 21 days of age. Impairments in triglyceride levels and cholesterol were also observed in these animals. Moreover, an increased heart weight/tibia length ratio was observed, indicating an enlarged heart. The overfed animals also had left ventricular hypertrophy with an increased area of cardiomyocytes and a decreased vessel density.
Our findings showed that overnutrition during early life induced obesity and cardiac hypertrophy in the pups, perhaps due to a decrease in the intramyocardial vessel.
Details
- Title: Subtitle
- Left ventricular hypertrophy induced by overnutrition early in life
- Creators
- A. Seixas Bello Moreira - Universidade do Estado do Rio de JaneiroM. Teixeira Teixeira - Laboratory of Nutrition Physiology and Development, Department of Physiology, Av. 28 de Setembro, 87-Rio de Janeiro, 20550-030 RJ, BrazilF. da Silveira Osso - Universidade do Estado do Rio de JaneiroR. Oliveira Pereira - Universidade do Estado do Rio de JaneiroG. de Oliveira Silva-Junior - Laboratory of Morphometry and Cardiovascular Morphology, Department of Anatomy, State University of Rio de Janeiro, BrazilE.P. Garcia de Souza - Laboratory of Nutrition Physiology and Development, Department of Physiology, Av. 28 de Setembro, 87-Rio de Janeiro, 20550-030 RJ, BrazilC.A. Mandarim de Lacerda - Laboratory of Morphometry and Cardiovascular Morphology, Department of Anatomy, State University of Rio de Janeiro, BrazilA. Sanchez Moura - Universidade do Estado do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Nutrition, metabolism, and cardiovascular diseases, Vol.19(11), pp.805-810
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.numecd.2009.01.008
- PMID
- 19359151
- ISSN
- 0939-4753
- eISSN
- 1590-3729
- Language
- English
- Date published
- 12/01/2009
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984420940502771
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