Journal article
Leishmania chagasi: a gene encoding a protein kinase with a catalytic domain structurally related to MAP kinase kinase
Experimental parasitology, Vol.82(2), pp.87-96
03/1996
DOI: 10.1006/expr.1996.0012
PMID: 8617352
Abstract
The gene for a serine/threonine protein kinase was isolated from Leishmania chagasi. The deduced amino acid sequence encoded by this Leishmania protein kinase (LPK-1) gene possesses all of the 11 conserved subdomains found in most other serine/threonine protein kinase catalytic domains. Sequence alignment with other known protein kinases demonstrates that the 42-kDa LPK-1 is a member of the mitogen-activated protein kinase kinase family involved in the signal-transduction pathways in yeast and mammalian cells. The single copy gene for LPK-1 specifies a 3.1-kb mRNA that is expressed in both logarithmic and stationary phase promastigotes with a twofold higher steady-state level in the infective stationary phase promastigotes.
Details
- Title: Subtitle
- Leishmania chagasi: a gene encoding a protein kinase with a catalytic domain structurally related to MAP kinase kinase
- Creators
- Shiyong Li - Department of Biochemistry, University of Iowa, Iowa City 52242, USAM E WilsonJ E Donelson
- Resource Type
- Journal article
- Publication Details
- Experimental parasitology, Vol.82(2), pp.87-96
- Publisher
- United States
- DOI
- 10.1006/expr.1996.0012
- PMID
- 8617352
- ISSN
- 0014-4894
- eISSN
- 1090-2449
- Grant note
- AI30126 / NIAID NIH HHS AI32135 / NIAID NIH HHS
- Language
- English
- Date published
- 03/1996
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984001120002771
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