Journal article
Leishmania infantum chagasi in Northeastern Brazil: Asymptomatic Infection at the Urban Perimeter
The American journal of tropical medicine and hygiene, Vol.86(1), pp.99-107
01/01/2012
DOI: 10.4269/ajtmh.2012.10-0492
PMCID: PMC3247116
PMID: 22232458
Abstract
Visceral leishmaniasis (VL) is endemic in large cities in Brazil, including Natal. We determined the prevalence of asymptomatic human infection with
Leishmania infantum chagasi
and associated environmental risks around Natal. Infection was detected by Leishmania skin test (LST) and anti-leishmanial antibodies in humans and anti-leishmanial antibodies in dogs. Amongst 345 humans, 24.6% were seropositive, and 38.6% were LST-positive. Prevalence of positive serology was similar in both sexes and across all ages. However, positive LST responses increased with age, suggesting that LST is long-lasting and cumulative. Multinomial logistic analysis showed that LST response varied with location (
P
= 0.007) and that males were more frequently LST-positive (
P
= 0.027). Indicators of lower socioeconomic status associated significantly with human infection. Furthermore, there was geographic coincidence of seropositive humans and dogs (
r
= 0.7926,
P
= 0.011). These data suggest that dog and human
L. i. chagasi
infection are intimately interrelated in environmental conditions associated with low income.
Details
- Title: Subtitle
- Leishmania infantum chagasi in Northeastern Brazil: Asymptomatic Infection at the Urban Perimeter
- Creators
- Iraci D Lima - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilJose W Queiroz - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilHenio G Lacerda - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilPaula V. S Queiroz - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilNubia N Pontes - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilJames D. A Barbosa - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilDaniella R Martins - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilJason L Weirather - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilRichard D Pearson - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilMary E Wilson - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), BrazilSelma M. B Jeronimo - Health Post-Graduate Program, Department of Infectious Diseases, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry and Department of Biology and Genetics, Biosciences Center, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil; Fundação Nacional de Saúde, Natal, RN, Brazil; Departments of Medicine and Pathology, University of Virginia, Charlottesville, Virginia; Interdisciplinary Graduate Program in Genetics, Departments of Internal Medicine, Microbiology, and Epidemiology, University of Iowa, Iowa City, Iowa; Veteran's Affairs Medical Center, Iowa City, Iowa; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT/CNPQ/MCT), Brazil
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.86(1), pp.99-107
- Publisher
- The American Society of Tropical Medicine and Hygiene
- DOI
- 10.4269/ajtmh.2012.10-0492
- PMID
- 22232458
- PMCID
- PMC3247116
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001133402771
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