Journal article
Leptin as a Mediator of Obesity-Induced Hypertension
Current obesity reports, Vol.5(4), pp.397-404
12/2016
DOI: 10.1007/s13679-016-0231-x
PMCID: PMC5119542
PMID: 27665107
Abstract
Hypertension and associated cardiovascular diseases represent the most common health complication of obesity and the leading cause of morbidity and mortality in overweight and obese patients. Emerging evidence suggests a critical role for the central nervous system particularly the brain action of the adipocyte-derived hormone leptin in linking obesity and hypertension. The preserved ability of leptin to cause cardiovascular sympathetic nerve activation despite the resistance to the metabolic actions of the hormone appears essential in this pathological process. This review describes the evidence supporting the neurogenic bases for obesity-associated hypertension with a particular focus on the neuronal and molecular signaling pathways underlying leptin's effects on sympathetic nerve activity and blood pressure.
Details
- Title: Subtitle
- Leptin as a Mediator of Obesity-Induced Hypertension
- Creators
- Balyssa B Bell - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAKamal Rahmouni - Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA. kamal-rahmouni@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Current obesity reports, Vol.5(4), pp.397-404
- DOI
- 10.1007/s13679-016-0231-x
- PMID
- 27665107
- PMCID
- PMC5119542
- NLM abbreviation
- Curr Obes Rep
- ISSN
- 2162-4968
- eISSN
- 2162-4968
- Publisher
- United States
- Grant note
- T32 GM067795 / NIGMS NIH HHS F31 HL134224 / NHLBI NIH HHS P01 HL084207 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040379002771
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