Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents

Chadi A Calarge; Vicki L Ellingrod; Bridget Zimmerman; Laura Acion; William I Sivitz; Janet A Schlechte

doi:10.1097/YPG.0b013e3283328e06

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Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents

Journal article

Open access

Peer reviewed

Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents

Chadi A Calarge, Vicki L Ellingrod, Bridget Zimmerman, Laura Acion, William I Sivitz and Janet A Schlechte

Psychiatric genetics, Vol.19(6), pp.320-327

12/2009

DOI: 10.1097/YPG.0b013e3283328e06

PMCID: PMC2919234

PMID: 19873684

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https://www.ncbi.nlm.nih.gov/pmc/articles/2919234View

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Abstract

As the use of atypical antipsychotics in children and adolescents has increased, concerns have been raised about their long-term safety. We aimed to investigate the association between risperidone-induced weight gain, leptin concentration, and the leptin gene (LEP) -2548G/A variants in youths. Medically healthy 7- to 17-year-old children and adolescents, in extended naturalistic treatment with risperidone, were recruited through pediatric psychiatry clinics. Anthropometric measures and laboratory testing were conducted. Growth and medication history was obtained from the medical record. The effect of the LEP genotypes on leptin concentration and on the slopes of the weight and body mass index (BMI) Z-score curves before and after the onset of risperidone treatment was investigated . In 74 individuals, chronically treated with risperidone, the A allele was associated with higher leptin concentration at low weight and BMI Z-scores. There was no effect of the LEP genotypes on weight or BMI Z-scores before risperidone was started. Afterwards, however, the A-allele carriers showed a steeper rate of increase in weight and BMI Z-scores. As a result, the GG-genotype carriers were 2.5 times less likely to be overweight/obese (i.e. having a BMI above the 85th percentile). This genetic effect on risperidone-associated weight gain did not extend to weight loss related to psychostimulants. The LEP - 2548G/A variants seem to moderate the weight-altering effect of risperidone but not psychostimulants. This may be related to genetic differences in tissue sensitivity to leptin, resulting in differential body composition.

Antipsychotic Agents - adverse effects

Base Sequence

Humans

Adolescent

Polymerase Chain Reaction

Risperidone - adverse effects

Female

Male

Weight Gain - drug effects

Leptin - genetics

DNA Primers

Child

Details

Title: Subtitle: Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents
Creators: Chadi A Calarge - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. chadi-calarge@uiowa.edu
Vicki L Ellingrod
Bridget Zimmerman
Laura Acion
William I Sivitz
Janet A Schlechte
Resource Type: Journal article
Publication Details: Psychiatric genetics, Vol.19(6), pp.320-327
DOI: 10.1097/YPG.0b013e3283328e06
PMID: 19873684
PMCID: PMC2919234
NLM abbreviation: Psychiatr Genet
ISSN: 0955-8829
eISSN: 1473-5873
Publisher: England
Grant note: M01 RR000059 / NCRR NIH HHS M01 RR000059-457089 / NCRR NIH HHS RR00059 / NCRR NIH HHS
Language: English
Date published: 12/2009
Academic Unit: Psychiatry; Biostatistics; Internal Medicine
Record Identifier: 9983997343902771

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