Lesion Mapping of Cognitive Abilities Linked to Intelligence

Jan Gläscher; Daniel Tranel; Lynn K Paul; David Rudrauf; Chris Rorden; Amanda Hornaday; Thomas Grabowski; Hanna Damasio; Ralph Adolphs

doi:10.1016/j.neuron.2009.01.026

Back

Lesion Mapping of Cognitive Abilities Linked to Intelligence

Journal article

Open access

Peer reviewed

Lesion Mapping of Cognitive Abilities Linked to Intelligence

Jan Gläscher, Daniel Tranel, Lynn K Paul, David Rudrauf, Chris Rorden, Amanda Hornaday, Thomas Grabowski, Hanna Damasio and Ralph Adolphs

Neuron (Cambridge, Mass.), Vol.61(5), pp.681-691

03/12/2009

DOI: 10.1016/j.neuron.2009.01.026

PMCID: PMC2728583

PMID: 19285465

Files and links (1)

url

https://doi.org/10.1016/j.neuron.2009.01.026View

Published (Version of record) Open Access

Abstract

The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of the index scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.

SYSNEURO

Details

Title: Subtitle: Lesion Mapping of Cognitive Abilities Linked to Intelligence
Creators: Jan Gläscher - Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA
Daniel Tranel - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Lynn K Paul - Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA
David Rudrauf - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Chris Rorden - Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA
Amanda Hornaday - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Thomas Grabowski - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Hanna Damasio - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA
Ralph Adolphs - Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.61(5), pp.681-691
DOI: 10.1016/j.neuron.2009.01.026
PMID: 19285465
PMCID: PMC2728583
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 03/12/2009
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002588002771

Metrics

29 Record Views

184 Times Cited - Web of Science