Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

Jan Gläscher; Ralph Adolphs; Hanna Damasio; Antoine Bechara; David Rudrauf; Matthew Calamia; Lynn K Paul; Daniel Tranel

doi:10.1073/pnas.1206608109

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Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

Journal article

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Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

Jan Gläscher, Ralph Adolphs, Hanna Damasio, Antoine Bechara, David Rudrauf, Matthew Calamia, Lynn K Paul and Daniel Tranel

Proceedings of the National Academy of Sciences - PNAS, Vol.109(36), pp.14681-14686

09/04/2012

DOI: 10.1073/pnas.1206608109

PMCID: PMC3437894

PMID: 22908286

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Abstract

A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several decades. We applied voxel-based lesion-symptom mapping in 344 individuals with focal lesions (165 involving the PFC) who had been tested on a comprehensive battery of neuropsychological tasks. Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching), which included the dorsolateral prefrontal cortex and anterior cingulate cortex and a second associated with value-based decision-making, which included the orbitofrontal, ventromedial, and frontopolar cortex. Furthermore, cognitive control tasks shared a common performance factor related to set shifting that was linked to the rostral anterior cingulate cortex. By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC.

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Details

Title: Subtitle: Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex
Creators: Jan Gläscher - University Medical Center Hamburg-Eppendorf
Ralph Adolphs - California Institute of Technology
Hanna Damasio - University of Southern California
Antoine Bechara - McGill University
David Rudrauf - Neurology and
Matthew Calamia - University of Iowa
Lynn K Paul - Humanities and Social Sciences and
Daniel Tranel - University of Iowa
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.109(36), pp.14681-14686
DOI: 10.1073/pnas.1206608109
PMID: 22908286
PMCID: PMC3437894
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Alternative title: Cognitive control and decision making in the PFC
Language: English
Date published: 09/04/2012
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002306502771

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