Journal article
Lesion network mapping demonstrates that mind‐wandering is associated with the default mode network
Journal of neuroscience research, Vol.99(1), pp.361-373
01/2021
DOI: 10.1002/jnr.24648
PMCID: PMC7704688
PMID: 32594566
Abstract
Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind‐wandering. Targeted lesion research has documented impairments in mind‐wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However, no lesion studies to date have applied lesion network mapping to identify common networks associated with deficits in mind‐wandering. In lesion network mapping, resting‐state functional connectivity data from healthy participants are used to infer which brain regions are functionally connected to each lesion location from a sample with brain injury. In the current study, we conducted a lesion network mapping analysis to test the hypothesis that lesions affecting the DMN and FPN would be associated with diminished mind‐wandering. We assessed mind‐wandering frequency on the Imaginal Processes Inventory (IPI) in participants with brain injury (n = 29) and healthy comparison participants without brain injury (n = 19). Lesion network mapping analyses showed the strongest association of reduced mind‐wandering with the left inferior parietal lobule within the DMN. In addition, traditional lesion symptom mapping results revealed that reduced mind‐wandering was associated with lesions of the dorsal, ventral, and anterior sectors of mPFC, parietal lobule, and inferior frontal gyrus in the DMN (p < 0.05 uncorrected). These findings provide novel lesion support for the role of the DMN in mind‐wandering and contribute to a burgeoning literature on the neural correlates of spontaneous cognition.
Using both novel and traditional lesion methods in humans, the neural networks responsible for mind‐wandering were studied. Both lesion analyses demonstrated that reduced mind‐wandering was associated with damage to brain regions within the default mode network.
Details
- Title: Subtitle
- Lesion network mapping demonstrates that mind‐wandering is associated with the default mode network
- Creators
- Carissa L Philippi - University of Missouri‐St. LouisJoel Bruss - University of Iowa Hospitals and ClinicsAaron D Boes - University of Iowa Hospitals and ClinicsFatimah M Albazron - University of Iowa Hospitals and ClinicsCarolina Deifelt Streese - University of Iowa Hospitals and ClinicsElisa Ciaramelli - University of BolognaDavid Rudrauf - University of GenevaDaniel Tranel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience research, Vol.99(1), pp.361-373
- DOI
- 10.1002/jnr.24648
- PMID
- 32594566
- PMCID
- PMC7704688
- NLM abbreviation
- J Neurosci Res
- ISSN
- 0360-4012
- eISSN
- 1097-4547
- Number of pages
- 13
- Grant note
- Kiwanis International Neuroscience Research Foundation National Institutes of Health (K12NS098482; P50 MH0942581; U01 NS103780)
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
- Record Identifier
- 9984070682702771
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