Lesions of the Anteroventral Third Ventricle and Development of Stress-Induced Hypertension in the Borderline Hypertensive Rat

Brian Sanders; Stein Knardahl; Alan Johnson

doi:10.1161/01.hyp.13.6.817

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Lesions of the Anteroventral Third Ventricle and Development of Stress-Induced Hypertension in the Borderline Hypertensive Rat

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Lesions of the Anteroventral Third Ventricle and Development of Stress-Induced Hypertension in the Borderline Hypertensive Rat

Brian Sanders, Stein Knardahl and Alan Johnson

Hypertension (Dallas, Tex. 1979), Vol.13(6, Part 2), pp.817-821

06/1989

DOI: 10.1161/01.hyp.13.6.817

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Abstract

The anteroventral third ventricle (AV3V) region plays a critical role in the pathogenesis of many forms of experimental hypertension. The present study sought to determine whether the integrity of this area was necessary for the development of stress-induced hypertension in the borderline hypertensive rat (BHR). Male BHRs were assigned to three groups at 8 weeks of age1) AV3V lesion, 2) sham lesion, and 3) maturation control. BHRs with AV3V and sham lesions were exposed to 12 weeks of conflict stress (2 hr/day, 5 days/wk). At the end of the conflict protocol period, direct measurement of resting mean arterial pressure indicated that BHRs w⁁ith sham lesions had significantly higher blood pressure (153±2.9 mm Hg) than rats with AV3V lesions (126+5.2 mm Hg) and maturation control rats (133±4.3 mm Hg). Although AV3V lesions prevented stress-induced hypertension in BHRs, these rats were still capable of transiently raising blood pressure. Specifically, the results also indicate that BHRs with AV3V lesions showed greater increases in blood pressure in response to an electric foot-shock paradigm. This study suggests a critical role for this forebrain region in the production of stress-induced hypertension in genetically predisposed animals.

Details

Title: Subtitle: Lesions of the Anteroventral Third Ventricle and Development of Stress-Induced Hypertension in the Borderline Hypertensive Rat
Creators: Brian Sanders - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa
Stein Knardahl
Alan Johnson
Resource Type: Journal article
Publication Details: Hypertension (Dallas, Tex. 1979), Vol.13(6, Part 2), pp.817-821
Publisher: American Heart Association, Inc
DOI: 10.1161/01.hyp.13.6.817
ISSN: 0194-911X
eISSN: 1524-4563
Language: English
Date published: 06/1989
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
Record Identifier: 9984213268602771

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