Lessons for COVID-19 Immunity from Other Coronavirus Infections

Alan Sariol; Stanley Perlman

doi:10.1016/j.immuni.2020.07.005

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Lessons for COVID-19 Immunity from Other Coronavirus Infections

Journal article

Open access

Peer reviewed

Lessons for COVID-19 Immunity from Other Coronavirus Infections

Alan Sariol and Stanley Perlman

Immunity (Cambridge, Mass.), Vol.53(2), pp.248-263

08/18/2020

DOI: 10.1016/j.immuni.2020.07.005

PMCID: PMC7359787

PMID: 32717182

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https://doi.org/10.1016/j.immuni.2020.07.005View

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Abstract

A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.

Betacoronavirus - pathogenicity

Coronavirus Infections - prevention & control

SARS Virus - immunology

Humans

Pandemics - prevention & control

Severe Acute Respiratory Syndrome - immunology

Coronavirus Infections - immunology

Middle East Respiratory Syndrome Coronavirus - immunology

Pneumonia, Viral - immunology

Betacoronavirus - immunology

COVID-19

SARS-CoV-2

Severe Acute Respiratory Syndrome - prevention & control

Animals

Pneumonia, Viral - prevention & control

Adaptive Immunity - immunology

CD8-Positive T-Lymphocytes - immunology

Viral Vaccines - immunology

Details

Title: Subtitle: Lessons for COVID-19 Immunity from Other Coronavirus Infections
Creators: Alan Sariol - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
Stanley Perlman - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: stanley-perlman@uiowa.edu
Resource Type: Journal article
Publication Details: Immunity (Cambridge, Mass.), Vol.53(2), pp.248-263
Publisher: United States
DOI: 10.1016/j.immuni.2020.07.005
PMID: 32717182
PMCID: PMC7359787
ISSN: 1074-7613
eISSN: 1097-4180
Grant note: P01 AI060699 / NIAID NIH HHS T32 GM067795 / NIGMS NIH HHS R01 AI129269 / NIAID NIH HHS
Language: English
Date published: 08/18/2020
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9984070312602771

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