Journal article
Lessons from the lily pad: using Xenopus to understand heart disease
Drug discovery today. Disease models, Vol.5(3), pp.141-146
2008
DOI: 10.1016/j.ddmod.2009.02.006
PMCID: PMC2747104
PMID: 19802378
Abstract
The developing embryos of the South African (
Xenopus laevis) and Western (
Xenopus tropicalis) clawed frogs provide an experimentally tractable and easily visualized model for vertebrate cardiovascular development. Most of the genes used to execute the cardiac developmental program are the same in frogs and humans. Experiments using
Xenopus provide an underutilized but valuable complement to studies on the molecular, cellular, physiological and morphological consequences of genetic and environmental influences on cardiac disease.
Ju Chen – University of California, San Diego, Department of Medicine, La Jolla, CA, USA
Robert Ross – University of California, San Diego, Cardiology Section, San Diego, CA, USA
Details
- Title: Subtitle
- Lessons from the lily pad: using Xenopus to understand heart disease
- Creators
- Heather L Bartlett - Department of Pediatrics, Roy J. and Lucille Carver College of Medicine, University of Iowa, United StatesDaniel L Weeks - Department of Biochemistry, Bowen Science Building, Roy J. and Lucille Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease models, Vol.5(3), pp.141-146
- DOI
- 10.1016/j.ddmod.2009.02.006
- PMID
- 19802378
- PMCID
- PMC2747104
- NLM abbreviation
- Drug Discov Today Dis Models
- ISSN
- 1740-6757
- eISSN
- 1740-6757
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2008
- Academic Unit
- Stead Family Department of Pediatrics; Biochemistry and Molecular Biology
- Record Identifier
- 9984024566002771
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