Journal article
Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol
Antimicrobial agents and chemotherapy, Vol.49(5), pp.2008-2014
05/2005
DOI: 10.1128/AAC.49.5.2008-2014.2005
PMCID: PMC1087661
PMID: 15855526
Abstract
Quinolones were examined for rapid lethal activity against Mycobacterium smegmatis in the presence and absence of chloramphenicol, an inhibitor of protein synthesis. C-8 methoxy, C-6 fluorine, and particular C-7 ring substituents enhanced rapid killing. With the surprising exception of moxifloxacin, higher quinolone concentrations were required for lethal activity in the presence of chloramphenicol than in its absence. Moxifloxacin was also unusual in lacking the time lag characteristic of fluoroquinolone lethality. Several fluoroquinolone dimers, which represent quinolones with large C-7 substituents, showed modest bacteriostatic activity. Unlike other quinolones, the dimers failed to display lethal activity. The insensitivity of moxifloxacin to chloramphenicol has not been observed with other bacteria and may therefore reflect unique aspects of mycobacterial gyrase.
Details
- Title: Subtitle
- Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol
- Creators
- Muhammad Malik - Public Health Research InstituteTao Lu - Public Health Research InstituteXilin Zhao - Public Health Research InstituteAnubha Singh - Public Health Research InstituteChristopher M Hattan - University of IowaJohn Domagala - PfizerRobert Kerns - University of IowaKarl Drlica - Public Health Research Institute
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.49(5), pp.2008-2014
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.49.5.2008-2014.2005
- PMID
- 15855526
- PMCID
- PMC1087661
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 05/2005
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365882302771
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